Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study

Bitencourt Reis, Caio Luiz; Nakane Matsumoto, Mirian Aiko; Baratto-Filho, Flares; Scariot, Rafaela; Sasso Stuani, Maria Bernadete; Lourenço Romano, Fábio; Della Coletta, Ricardo; Silva Barroso de Oliveira, Daniela; Proff, Peter; Kirschneck, Christian; Calvano Küchler, Erika

doi:10.1186/s13005-023-00372-3

Table 4 Genotype distribution among skeletal maturity groups

From: Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study

Genetic variation (Gene)	Model	Genotype	Normal		Delayed		p-value (Normal vs. Delayed)	Advanced		p-value (Normal vs. Advanced)
Genetic variation (Gene)	Model	Genotype	n	%	n	%	p-value (Normal vs. Delayed)	n	%	p-value (Normal vs. Advanced)
rs708111 (WNT3A)	Co-Dominant	GG	18	33.96	5	19.23	Reference	1	6.7	Reference
		AG	23	43.40	10	38.46	0.685	10	66.7	0.064^#
		AA	12	22.64	11	42.31	0.066	4	26.6	0.096
	Dominant	GG	18	33.96	5	19.23	Reference	1	6.7	Reference
	Dominant	AG + AA	35	66.04	21	80.77	0.175	14	93.3	0.064^#
	Recessive	GG + AG	41	77.36	15	57.69	Reference	11	73.3	Reference
	Recessive	AA	12	22.64	11	42.31	0.070	4	26.7	0.747
	Allele	G	59	55.66	20	38.46	Reference	12	40.00	Reference
	Allele	A	47	44.34	32	61.54	0.042*	18	60.00	0.131
rs1533767 (WNT11)	Co-Dominant	GG	25	60.98	7	38.89	Reference	6	50.0	Reference
		AG	13	31.71	11	61.11	0.059	6	50.0	0.330
		AA	3	7.32	0	0.00	†	0	0.0	†
	Dominant	GG	25	60.98	7	38.89	Reference	6	50.0	Reference
	Dominant	AG + AA	16	39.02	11	61.11	0.116^#	6	50.0	0.501
	Recessive	GG + AG	38	92.68	18	100.00	Reference	12	100.0	Reference
	Recessive	AA	3	7.32	0	0.00	†	0	0.0	†
	Allele	G	63	76.82	25	69.44	Reference	18	75.00	Reference
	Allele	A	19	23.18	11	30.56	0.398	6	25.00	0.853
rs1200425 (RUNX2)	Co-Dominant	GG	20	37.74	7	30.43	Reference	6	42.86	Reference
		AG	24	45.28	8	34.78	0.826	7	50.00	0.785
		AA	9	16.98	8	34.78	0.266	1	7.14	0.709#
	Dominant	GG	20	37.74	7	30.43	Reference	6	42.86	Reference
	Dominant	AG + AA	33	62.26	16	69.57	0.541	8	57.14	0.726#
	Recessive	GG + AG	44	83.02	15	65.22	Reference	13	92.86	Reference
	Recessive	AA	9	16.98	8	34.78	0.087	1	7.14	0.358
	Allele	G	64	60.38	22	47.83	Reference	19	67.86	Reference
	Allele	A	42	39.62	24	52.17	0.151	9	32.14	0.468
rs59983488 (RUNX2)	Co-Dominant	GG	18	34.62	11	44.00	Reference	7	50.00	Reference
		TG	13	25.00	3	12.00	0.320	4	28.57	0.972
		TT	21	40.38	11	44.00	0.982	3	21.43	0.321
	Dominant	GG	18	34.62	11	44.00	Reference	7	50.00	Reference
	Dominant	TG + TT	34	65.38	14	56.00	0.763#	7	50.00	0.292#
	Recessive	GG + TG	31	59.62	14	56.00	Reference	11	78.57	Reference
	Recessive	TT	21	40.38	11	44.00	0.426#	3	21.43	0.190#
	Allele	G	49	47.12	25	50.00	Reference	18	64.29	Reference
	Allele	T	55	52.88	25	50.00	0.737	10	35.71	0.106

Notes: Normal group was used as control for comparisons. Chi-square test was performed, except p-values with ^#, which was performed by Fisher test. * statistical significance (p < 0.05). † means that the test was not performed

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ISSN: 1746-160X

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