- Open Access
- Open Peer Review
MRI in detecting facial cosmetic injectable fillers
- Sigal Tal†1, 3,
- Hillel S. Maresky†1, 3Email author,
- Theodore Bryan1,
- Ella Ziv2,
- Dov Klein2,
- Assaf Persitz2 and
- Lior Heller2
© The Author(s). 2016
- Received: 8 April 2016
- Accepted: 2 August 2016
- Published: 6 September 2016
Despite being considered a non-invasive procedure, injections can cause adverse outcomes including infections, overfilling, asymmetry, foreign body granulomas, and reactions that lead to scarring. Complications may be associated with the procedure itself, the physician’s technique, and/or the type of agent injected. In these instances, it is important to be able locate and identify the substance used. This study investigated the viability of using MRI to correctly identify injected substances, their symmetry of distribution, and related complications.
Fourteen patients with suspected injectable filler complications were identified by our institution’s plastic surgery service. All subjects were scanned with MRI, using highly specific face-oriented sequences at high resolution with small field of view and thin slices across the axial and coronal planes by T1 Dixon non-contrast, T2 Dixon, and T1 Dixon after gadolinium injection. Two independent and blinded radiologists evaluated the images and reported (1) the likely injected substance, (2) symmetry, and (3) complications. These radiological results were compared against clinical data provided by the plastic surgery service.
Ten patients (83 %) presented objective injectable complications: 4 had abscess, 4 granulomata, and 2 had allergic reactions to the injected substance. The Fleiss Kappa for inter-rater agreement on substances was 0.80. Asymmetry was identified in six patients (50 %) with a Kappa between radiology evaluators of 1. MRI characteristics of these common fillers are summarized in table form.
Given the growing awareness among referring physicians of the value of dedicated facial MRI, utilization of this imaging technique may lead to discovery of the injected substance’s true identity, evaluation of symmetry and/or complications.
- Hyaluronic Acid
- Gadolinium Injection
- Foreign Body Granuloma
- Dermal Filler
As the use of cosmetic injectable fillers continues to rise, so does the incidence of complications. Fillers are commonly administered in office settings by non-specialists and are minimally regulated in many countries . In some cases, the identity of the substance may be unknown or misrepresented. Despite being considered a non-invasive procedure, injections can cause adverse outcomes including infections, overfilling, asymmetry, foreign body granulomas, and reactions that lead to scarring . Complications may be associated with the procedure itself, the physician’s technique, and/or the type of agent injected. In these instances, it is important to be able locate and identify the substance used.
On the molecular level, injectable fillers are designed to last different lengths of time, and can be categorized as short (0–3 months), medium (3–12 months), or long-term (12 months to indefinitely) . Collagen, hyaluronic acid, and silicone are examples of commonly used short, medium, and long-term fillers, respectively. Generally speaking, shorter-term products have greater biocompatibility . Depending on the type of filler used, complication rates range from 3 % to 52 % . In the short term, adverse events can include bleeding, infections, edema, and migration. In the long term, there is a risk of lump formation, granulomas, abscesses, more diffuse edema, and skin discoloration . In these cases, having a reliable way to identify unknown substances prior to surgical treatment would be of great value both medically and legally . Attenuated total reflectance/Fourier transform infrared spectroscopy can accurately identify unknown injectable fillers . However, this method requires surgical specimen collection, which can lead to undesirable scarring. Spectrophotometers are not commonly found in radiology units, and their implementation requires additional cost outlays and training. Thus clearly, a more ubiquitous and less invasive modality would be advantageous.
MRI and CT studies have documented the features of many common injectable fillers and their related sequelae, and can distinguish them from normal tissues . Calcium hydroxylapatite produces low-to-intermediate signal intensity on T1 and T2 . Collagen fillers are low signal on T1 and high signal on T2. Hyaluronic acid has a relaxation time of 600 ms on T2 . Polyacrylamide is high intensity on T2 and low intensity on T1 . Silicone is hyperintense to water on T1 and either hypointense or isointense on T2, depending on the viscosity of the specific product . However, these descriptions are only useful when the identity of the filler is known and there is simply a need for visualization. Girolamo et al. showed that granulomatous reactions to fillers produced subcutaneous contrast enhancement with IV gadolinium, and found that MRI could be used to detect dermal fillers down to a minimum size of 2 mm without reliance on clinical evaluation . Kadouch et al. assessed the extent of agreement between clinical evaluations of injectable filler-related complications and an independent MRI evaluation , and found good concordance in uncomplicated cases (85 %), but not in cases with inflammation or migration (32 and 9 %, respectively).
This study investigated the feasibility of using a dedicated imaging protocol for the assessment of all filler-related procedures and related complications, independent of expert clinical input. We show that by the addition of a high resolution face MRI using T1 T2 Dixon with a fat and water suppression technique, radiologists can identify fillers in unexpected locations, and differentiate different kinds of facial fillers.
Dermal filler characteristics on T1 weighted, T2 weighted, T1 Fat Saturation (T1FS), T2 Fat Saturation (T2FS) sequences
A prospective analysis was performed on all patients above the age of 18 who underwent dedicated face MRI after injection of intradermal fillers at our institution between 2013 and 2015. These patients were referred to our imaging department from the plastic surgery department and outpatient clinics as well as from private esthetic clinics after complaining of asymmetry, facial pain, or both.
All the patients’ faces were examined with a Siemens Magnetom Skyra 3 Tesla MRI, using highly specific face-oriented sequences with high resolution and a small field of view (voxel size: 0.3*0.3*4.0 mm – 0.5*0.5*4.0 mm). Thin slices (3–4 mm) across axial and coronal planes were acquired using the following sequences: T1 Dixon fast spin echo (FSE) sequence non-contrast (TR 5610.0 ms, TE 79.0 ms, Flip angle 150 deg), with and without FS, T2 Dixon FSE non-contrast (TR 3800.0 ms, TE 103.0 ms, Flip angle 160 deg), with and without FS, and T1 Dixon FSE after gadolinium injection (TR 576.0 ms, TE 11 ms, Flip angle 131 deg), with and without FS. Axial, coronal and sagital acquisitions were used, with a total scan time of approximately 38 min.
Imaging evaluation and clinical correlation
Two independent radiologists with 30 years’ combined experience in radiology volunteered to be evaluators, and were blinded to the identity of substances used, the clinical history and information related to the plastic surgeon. They drew conclusions on the identity of the substance, and graded complications and degree of asymmetry (both on a scale of 1–2), based solely on MRI imaging. When disagreements occurred they submitted their conclusions to a third party with 20 years of experience, also blinded, who decided on likely substance identity. Kappa inter-rater tests were conducted for substance identity, degree of complications and degree of asymmetry, and compared to the surgeons’ files.
Fourteen subjects who underwent MRI using the above protocol took part in the study after signing consent forms. Thirteen females (93 %) and one male (7 %) were examined, with an average age of 46.8 years. The average time between intradermal injection and MRI scanning was 51 days; three patients (22 %) underwent repeat MRI at an average time from filler to MRI of 82 days. Seven patients underwent polyacrylamide gel injection (50 %), three hyaluronic acid (22 %), two silicone (14 %), and two collagen (14 %). The inter-rater agreement between the two evaluators for substance was a high 0.80 using the Fleiss Kappa and after consensus between the two evaluators, the Kappa between imaging and clinical data was 0.96 (near perfect). While polyacrylamide and hyaluronic acid were easily identified (K = 0.86 and 0.84, respectively), silicone and collagen showed greater disparity between the evaluators (K = 0.77 and 0.69, respectively).
MRI detected four cases of (36 %) abscesses, four cases (36 %) granulomata, and three (28 %) cases of allergic reactions to injected substances. Key imaging features of abscesses included ring enhancement after gadolinium injection, while granulomata demonstrated diffuse signal intensity on T1 and T2 without ring enhancement. Allergic reactions were distinguished by the presence of “patchy” signal on all sequences and fat stranding on non fat saturated sequences around the injected substance, without enhancement after gadolinium injection. The Kappa agreement between evaluators for the presence or absence of complications was 1.0 (perfect agreement), and 0.76 for degree of severity. MRI visualized asymmetry in (50 %) of cases and the kappa agreement between evaluators on the presence or absence of asymmetry was 1.0 and 0.72 respectively, with respect to severity.
These results show that facially oriented MRI with contrast is a reliable tool to accurately locate fillers, and identify unintended outcomes such as migration, abscess formation, granuloma, and delayed allergic reaction. The use of a dedicated facial MRI with high spatial resolution and elaborate Dixon sequences not only gives the interpreting radiologist the ability to make a clear-cut decision on the identity of a substance, but also provides the referring plastic surgeon with a better understanding of disease pathology and pathophysiology. In addition to its clinical utility, MRI can provide forensic evidence to medico/legal cases involving injected materials.
The main limitation of our study is sample size. There are other types of facial filler substances on the market than are represented in the sample, and we have not yet had the opportunity to characterize them using our novel MRI technique. Several non-face dedicated techniques have been published in the literature [5, 7], and we did not perform a randomized trial to compare our technique to others; however, the robustness of the Dixon sequences used, which include fat suppression and high resolution field of view, alongside the added value of gadolinium injection, serves as a precise and accurate all-encompassing facial imaging technique. The imaging and clinical utility of this technique was highlighted by our high inter-rater statistics and exquisite images.
Our reference table will be updated each time we encounter cases of complications involving substances not yet seen. Given the growing awareness among referring physicians of the value of dedicated facial MRI with gadolinium injection, we expect to see rising numbers of MRIs performed on cases with and without complications after cosmetic intradermal injectable filler procedures, to evaluate for symmetry and help referring clinicians to provide their post-filler patients with the best possible health and esthetic outcomes.
MRI, magnetic resonance imaging; IRB, institutional review board; US, United States; UK, United Kingdom
We thank Prof. Simon Strauss for his ever-invaluable insight and Dr. Paul Gottlieb for his encouragement and support of a research driven atmosphere. These authors mention and humbly console the family of our beloved teacher, the late Prof. Moshe Graif, z”l, whose everlasting impression on our souls will continue to pique our curiosity and passion for imaging, and whose memory will surely not fade away by his recent passing.
No sources of funding to declare.
Availability of data and materials
All data generated or analysed during this study are included in the published article and its Additional files are available upon request.
ST & HSM conceived the study design and drafted the manuscript equally. TB collected patient data, compiled information and co-ordinated the double-blind Kappa agreements. EZ performed statistical analysis. AP, DK & LH participated in the study’s design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests and no conflicts of interests to disclose.
Consent for publication
The patients gave their informed consent to publish their MRI images and photographs. The consent form is available to the Editor-in-Chief upon request.
Ethics approval and consent to participate
All patients agreed to participate in this study and consented to their MRI images and pictures to be studied and published. This study was approved by the hospital’s Helsinki committee and filed under Assaf Harofeh Medical Center IRB 99/14. All patients gave their informed consent to participate in the study. The consent form is available to the Editor-in-Chief upon request.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Goldberg DJ. Legal ramifications of off-label filler use. Dermatol Ther. 2006;19(3):189–93.View ArticlePubMedGoogle Scholar
- Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Plast Surg Nurs. 2015;35(1):13–32.View ArticlePubMedGoogle Scholar
- Sánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. Dermal Fillers: Types, Indications, and Complications. Actas Dermo-Sifiliográficas (English Edition). 2010;101(5):381–93.View ArticleGoogle Scholar
- Maas CS, et al. Complications of injectable synthetic polymers in facial augmentation. Dermatol Surg. 1997;23(10):871–7.View ArticlePubMedGoogle Scholar
- Di Girolamo M, et al. MRI in the evaluation of facial dermal fillers in normal and complicated cases. Eur Radiol. 2015;25(5):1431–42.View ArticlePubMedGoogle Scholar
- Persichetti P, et al. Dermal Filler Complications from Unknown Biomaterials: Identification by Attenuated Total Reflectance Spectroscopy. Plast Reconstr Surg. 2013;131(4):597e–603e.View ArticlePubMedGoogle Scholar
- Ginat DT, Schatz CJ. Imaging Features of Midface Injectable Fillers and Associated Complications. Am J Neuroradiol. 2013;34(8):1488–95.View ArticlePubMedGoogle Scholar
- Feeney JN, Fox JJ, Akhurst T. Radiological impact of the use of calcium hydroxylapatite dermal fillers. Clin Radiol. 2009;64(9):897–902.View ArticlePubMedGoogle Scholar
- Mathews VP, et al. Intraocular silicone oil: in vitro and in vivo MR and CT characteristics. AJNR Am J Neurorad iol. 1994;15(2):343–7.Google Scholar
- Kadouch JA, et al. Complications After Facial Injections With Permanent Fillers: Important Limitations and Considerations of MRI Evaluation. Aesthet Surg J. 2014;34(6):913–23.View ArticlePubMedGoogle Scholar
- Mercer NSG. Dermal fillers are medical devices in the UK. BMJ. 2009;339:b2923.View ArticlePubMedGoogle Scholar
- Wollina U, Goldman A. Dermal fillers: Facts and controversies. Clin Dermatol. 2013;31(6):731–6.View ArticlePubMedGoogle Scholar
- Pickett A. Serious issues relating to counterfeit dermal fillers available from Internet sources. J Am Acad Dermatol. 2011;65(3):642–3.View ArticlePubMedGoogle Scholar
- Lemperle G, Duffy DM. Treatment options for dermal filler complications. Aesthet Surg J. 2006;26(3):356–64.View ArticlePubMedGoogle Scholar
- Reisberger EM, et al. Foreign body granulomas caused by polymethylmethacrylate microspheres: successful treatment with allopurinol. Arch Dermatol. 2003;139(1):17–20.View ArticlePubMedGoogle Scholar
- Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009;35 Suppl 2:1672–80.View ArticlePubMedGoogle Scholar
- Styperek A, et al. Nonmedical-grade Injections of Permanent Fillers: Medical and Medicolegal Considerations. J Clin Aesthetic Dermatol. 2013;6(4):22–9.Google Scholar
- Engelman DE, Bloom B, Goldberg DJ. Dermal fillers: complications and informed consent. J Cosmet Laser Ther. 2005;7(1):29–32.View ArticlePubMedGoogle Scholar
- Khawaja AZ, et al. Revisiting the risks of MRI with Gadolinium based contrast agents—review of literature and guidelines. Insights Into Imaging. 2015;6(5):553–8.View ArticlePubMedPubMed CentralGoogle Scholar