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Dentin dysplasia type I: a challenge for treatment with dental implants
© Depprich et al; licensee BioMed Central Ltd. 2007
Received: 03 July 2007
Accepted: 22 August 2007
Published: 22 August 2007
Dentin dysplasia type I is characterized by a defect of dentin development with clinical normal appearance of the permanent teeth but no or only rudimentary root formation. Early loss of all teeth and concomitant underdevelopment of the jaws are challenging for successful treatment with dental implants.
A combination of sinus lifting and onlay bone augmentation based on treatment planning using stereolithographic templates was used in a patient with dentin dysplasia type I to rehabilitate the masticatory function.
(i) a predisposition for an increased and accelerated bone resorption was observed in our patient, (ii) bone augmentation was successful using a mixture of allogenic graft material with autogenous bone preventing fast bone resorption, (iii) surgical planning, based on stereolithographic models and surgical templates, facilitated the accurate placement of dental implants.
Bony augmentation and elaborate treatment planning is helpful for oral rehabilitation of patients with dentin dysplasia type I.
Dentin dysplasia is a defect of dentin development that is inherited as an autosomal dominant trait and classified into two types [1, 2]. Dentin dysplasia type I is characterized by the presence of primary and permanent teeth with normal appearance of the crown but no or only rudimentary root development, incomplete or total obliteration of the pulp chamber and periapical radiolucent areas or cysts. Dentin dysplasia type II is characterized by primary teeth with complete pulpal obliteration and brown or amber bluish coloration similar to that seen in hereditary opalescent dentin. The permanent teeth have a normal appearance or a slight amber coloration, the roots are normal in size and shape with a thistle-tube-shaped pulp chamber with pulp stones [3, 4].
The sequelae of dentin dysplasia are difficult to manage and provide a challenge for the dentist concerning restorative and endodontic treatment but also prosthetic treatment after loss of teeth . This report describes the implant based oral rehabilitation of a patient with dentin dysplasia type I including aesthetic considerations, treatment planning using stereolithographic templates and tissue regeneration.
A 17-year-old girl with a history of dentin dysplasia type I but no other serious diseases, came to our departement for consultation complaining her loose teeth and asking for prosthetic treatment. The girl's mother suffered from the same disease and her edentulous jaws were treated with removable prostheses.
Dentin dysplasia type I is characterized by primary and permanent teeth with normal appearance of the crown but no or only rudimentary root development, incomplete or total obliteration of the pulp chamber and periapical radiolucent areas or cysts [1, 2]. The abnormal root morphology is postulated secondary to the abnormal differentiation and/or function of the ectomesenchymally derived odontoblasts . Although various treatment strategies including conventional endodontic therapy, periapical curettage or preventive regimen have been proposed to maintain the teeth as long as possible, early exfoliation of the teeth and maxillomandibular atrophy as a consequence of abnormal root development, periapical abscesses or cystic formations are characteristics of dentin dysplasia type I .
Successful oral rehabilitation with complete denture after extraction of all teeth and curettage of cysts has been described .
When implant supported prostheses are planned in patients affected by dentin dysplasia type I bone regenerative therapy is required. Munoz-Guerra et al. reported successfull treatment of a 24-year old girl after onlay bone grafting and sinus augmentation . The authors used cortico-cancellous bone blocks from the iliac crest for onlay grafting and and a mixture of autologous bone graft and an autologous platelet concentrate obtained from platelet-rich plasma for the sinus lift procedure. The teeth were extracted 4 months after bone augmentation was performed. No increased and accelerated bone resorption was observed.
In our patient, extraction of all teeth, cystectomy, bilaterally sinus lifting and onlay bone grafting with autogenous bone grafts were performed as the initial surgical procedure. Already 2 months after bone grafting first signs of bone resorption were noted.
Resorption of grafted bone is a well known phenomena that arises during healing and osseointegration processes and as the result of non physiological loading . Bell et al. found a 33% resorption rate of mandibular onlay grafts from the iliac crest during the 4 to 6 months before implant placement. After implant placement resorption rate decreased considerably . Several investigations revealed a high resorption rate of autogenous bone grafts in the period after grafting and before implant placement and therefore recommend a mixture of autogenous bone with allografts [12, 13] or stabilizing titanium mesh for vertical alveolar ridge augmentation . Nevertheless the presence of a dehiscence defect irrespective of the augmentation treatment used increases the resorption rate . Bone grafting simultaneous to implant placement has been published to be a proper strategy as this can reduce the number of surgical interventions and additionally fix the implant itself . However a staged procedure is recommended to achieve better implant positioning after graft consolidation. When iliac bone is used, second surgeries may be performed at 4 to 6 months . After an uneventful healing period of 6 month the grafted bone around the implants will have a prognosis similar to that of nongrafted bone . The application of autologous blood plasma enriched with thrombocytes by centrifugal concentration (platelet-rich plasma: PRP) has been accredited to enhance the formation of new bone and improve incorporation and preservation of bone grafts . Platelet-rich plasma (PRP) is being used to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factors released from the platelets include platelet-derived growth factor, transforming growth factor beta, platelet-derived epidermal growth factor, platelet-derived angiogenesis factor, insulin-like growth factor 1, and platelet factor 4. These factors signal the local mesenchymal and epithelial cells to migrate, divide, and increase collagen and matrix synthesis. However there is still lack of scientific evidence to support the effect of PRP on osteogenic induction and the use of PRP in combination with bone grafts during augmentation procedures [20, 21]. Although Thor et al. could not demonstrate obvious positive effects of PRP on bone graft healing the authors observed that the handling of the particulated bone grafts was improved .
In our patient implant placement was performed as a second stage procedure. A short period after onlay bone grafting and sinus lifting a high degree bone resorption had occurred, although healing was uneventfull and no dehiscence defect had occured. In this situation presurgical implant planning using 3D images (SimPlant® technology) was a helpful tool in this anatomic difficult situation. We were able to take into account not only the present bone volume and morphology but also aesthetic considerations regarding the prosthetic treatment. Implant placement was facilitated by the use of osseous-borne stereolithographic drilling guides. To prevent further extensive secondary bone resorption the principle of guided bone regeneration was used during the second procedure. In the present case, despite the hypothesized increased resorption activity, the secondary performed bone augmentation with a mixture of allogenic materials and autogenous bone in combination with a resorbable membrane provided a successful longterm result. Munoz-Guerra et al. recommend a two stage procedure and the use of autologous cortico-cancellous grafts from the iliac crest for treatment of their patient with dentin dysplasia type I . In contrast to our case Munoz-Guerra et al. did not find an increased affinity for bone resorption in their patient, but they did not perform tooth extraction and cystectomy before bone augmentation but removed the teeth 4 months after onlay bone grafting and sinuslifting was performed. Whether this is the crucial difference in treatment strategy or whether patients afflicted by dentin dysplasia I posses an increased affinity for bone resorption has to be discovered by future research.
Oral rehabilitation of patients with dentin dysplasia type I requires elaborate treatment planning. Surgical implant planning based on stereolithographic technique is a helpful tool in such cases. As we found an increased affinity for bone resorption in our patient we recommend guided bone regeneration using a decelerated biodegradable collageneous membrane and a mixture of autogenous bone with non resorbable grafting material.
We thank our patient and her parents for consenting to publication of this case.
- O Carroll MK, Duncan WK: Dentin dysplasia type I. Radiologic and genetic perspectives in a six-generation family. Oral Surg Oral Med Oral Pathol. 1994, 78 (3): 375-381. 10.1016/0030-4220(94)90071-X.View ArticlePubMedGoogle Scholar
- Shields ED, Bixler D, el-Kafrawy AM: A proposed classification for heritable human dentine defects with a description of a new entity. Arch Oral Biol. 1973, 18 (4): 543-553. 10.1016/0003-9969(73)90075-7.View ArticlePubMedGoogle Scholar
- O Carroll MK, Duncan WK, Perkins TM: Dentin dysplasia: review of the literature and a proposed subclassification based on radiographic findings. Oral Surg Oral Med Oral Pathol. 1991, 72 (1): 119-125. 10.1016/0030-4220(91)90202-N.View ArticlePubMedGoogle Scholar
- Ommerborn M, Raab W: Allgemeinerkrankungen und Schäden der Zahnhartsubstanzen. Prophylaxe Impuls. 2005, 9: 66-73.Google Scholar
- Pettiette MT, Wright JT, Trope M: Dentinogenesis imperfecta: endodontic implications. Case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998, 86 (6): 733-737. 10.1016/S1079-2104(98)90213-X.View ArticlePubMedGoogle Scholar
- Melnick M, Levin LS, Brady J: Dentin dysplasia type I: a scanning electron microscopic analysis of the primary dentition. Oral Surg Oral Med Oral Pathol. 1980, 50 (4): 335-340. 10.1016/0030-4220(80)90418-1.View ArticlePubMedGoogle Scholar
- Shankly PE, Mackie IC, Sloan P: Dentinal dysplasia type I: report of a case. Int J Paediatr Dent. 1999, 9 (1): 37-42. 10.1046/j.1365-263x.1999.00106.x.View ArticlePubMedGoogle Scholar
- Neumann F, Wurfel F, Mundt T: Dentin dysplasia type I--a case report. Ann Anat. 1999, 181 (1): 138-140.View ArticlePubMedGoogle Scholar
- Munoz-Guerra MF, Naval-Gias L, Escorial V, Sastre-Perez J: Dentin dysplasia type I treated with onlay bone grafting, sinus augmentation, and osseointegrated implants. Implant Dent. 2006, 15 (3): 248-253. 10.1097/01.id.0000234638.60877.1b.View ArticlePubMedGoogle Scholar
- Burchardt H: Biology of bone transplantation. Orthop Clin North Am. 1987, 18 (2): 187-196.PubMedGoogle Scholar
- Bell RB, Blakey GH, White RP, Hillebrand DG, Molina A: Staged reconstruction of the severely atrophic mandible with autogenous bone graft and endosteal implants. J Oral Maxillofac Surg. 2002, 60 (10): 1135-1141. 10.1053/joms.2002.34986.View ArticlePubMedGoogle Scholar
- Pejrone G, Lorenzetti M, Mozzati M, Valente G, Schierano GM: Sinus floor augmentation with autogenous iliac bone block grafts: a histological and histomorphometrical report on the two-step surgical technique. Int J Oral Maxillofac Surg. 2002, 31 (4): 383-388. 10.1054/ijom.2002.0286.View ArticlePubMedGoogle Scholar
- Szabo G, Huys L, Coulthard P, Maiorana C, Garagiola U, Barabas J, Nemeth Z, Hrabak K, Suba Z: A prospective multicenter randomized clinical trial of autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevation: histologic and histomorphometric evaluation. Int J Oral Maxillofac Implants. 2005, 20 (3): 371-381.PubMedGoogle Scholar
- Roccuzzo M, Ramieri G, Bunino M, Berrone S: Autogenous bone graft alone or associated with titanium mesh for vertical alveolar ridge augmentation: a controlled clinical trial. Clin Oral Implants Res. 2007, 18 (3): 286-294. 10.1111/j.1600-0501.2006.01301.x.View ArticlePubMedGoogle Scholar
- Chen ST, Darby IB, Adams GG, Reynolds EC: A prospective clinical study of bone augmentation techniques at immediate implants. Clin Oral Implants Res. 2005, 16 (2): 176-184. 10.1111/j.1600-0501.2004.01093.x.View ArticlePubMedGoogle Scholar
- Penarrocha-Diago M, Gomez-Adrian MD, Garcia-Mira B, Ivorra-Sais M: Bone grafting simultaneous to implant placement. Presentation of a case. Med Oral Patol Oral Cir Bucal. 2005, 10 (5): 444-447.PubMedGoogle Scholar
- Triplett RG, Schow SR: Autologous bone grafts and endosseous implants: complementary techniques. J Oral Maxillofac Surg. 1996, 54 (4): 486-494. 10.1016/S0278-2391(96)90126-3.View ArticlePubMedGoogle Scholar
- Widmark G, Andersson B, Carlsson GE, Lindvall AM, Ivanoff CJ: Rehabilitation of patients with severely resorbed maxillae by means of implants with or without bone grafts: a 3- to 5-year follow-up clinical report. Int J Oral Maxillofac Implants. 2001, 16 (1): 73-79.PubMedGoogle Scholar
- Thor A, Wannfors K, Sennerby L, Rasmusson L: Reconstruction of the severely resorbed maxilla with autogenous bone, platelet-rich plasma, and implants: 1-year results of a controlled prospective 5-year study. Clin Implant Dent Relat Res. 2005, 7 (4): 209-220. 10.1111/j.1708-8208.2005.tb00066.x.View ArticlePubMedGoogle Scholar
- Arpornmaeklong P, Kochel M, Depprich R, Kubler NR, Wurzler KK: Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. Int J Oral Maxillofac Surg. 2004, 33 (1): 60-70. 10.1054/ijom.2003.0492.View ArticlePubMedGoogle Scholar
- Klongnoi B, Rupprecht S, Kessler P, Zimmermann R, Thorwarth M, Pongsiri S, Neukam FW, Wiltfang J, Schlegel KA: Lack of beneficial effects of platelet-rich plasma on sinus augmentation using a fluorohydroxyapatite or autogenous bone: an explorative study. J Clin Periodontol. 2006, 33 (7): 500-509. 10.1111/j.1600-051X.2006.00938.x.View ArticlePubMedGoogle Scholar
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