- Open Access
- Open Peer Review
A retrospective analysis of the relationship between rhinosinusitis and sinus lift dental implantation
© Kayabasoglu et al.; licensee BioMed Central. 2014
- Received: 16 April 2014
- Accepted: 2 November 2014
- Published: 15 December 2014
Dental implants have been associated with the occurrence of postoperative rhinosinusitis. In some patients, preoperative sinus lifting must be performed to increase the chances of successful implant placement. This retrospective study examines the relationship of dental implants after sinus lifting with the occurrence of postoperative rhinosinusitis.
A total of 268 dental implants were inserted in 94 patients (62 Males, 32 Females) between 2011–2013. The ages ranged from 29–71 (in males) and 33–64 (in females). Additionally, bilateral sinus lifing was performed in 51 patients, and unilateral sinus lifting was performed in 43 of the patients. Patients were evaluated for sinus pathology for a period of 5–47 months postoperatively using a satisfaction questionnaire, conventional radiographic examination, and nasal endoscopic examination.
Four of the patients (4.2%) had a complication of postoperative sinusitis and were treated medically. In one patient, the implant was unsuccessful (even after treatment) and was removed. None of the patients needed surgery due to the sinusitis or any associated complications.
The risk for postoperative rhinosinusitis was found to be higher in patients who suffer from chronic sinusitis and in cases in which a large amount of graft was utilized for sinus lifting. These predisposing factors need to be considered when evaluating patients for dental implants and sinus lift procedures.
- Dental implant
- Maxillary sinusitis
- Sinus lift
The posterior edentulous maxilla is often seen as a challenge for the oral surgeon as alveolar ridge reabsorption and maxillary sinus pneumatization decreases the bone available for implant stabilization. As such, edentulous alveolar ridges are considered unfavorable for implant placement [2–4]. In cases where there is insufficient bone to provide support for dental implants, bone grafting may be considered. Dentists often perform sinus mucosal lifting procedures to increase the safety factor of bone grafting . Autogenous bone grafting to augment the maxillary sinus floor is a generally accepted pre-implant procedure that facilitates the successful placement of endosseous implants in the correct prosthetic position [6, 7]. In these cases, complications related to sinusitis can occur during the grafting of bone, during the sinus lift, or after the completion of the sinus lift .
In contrast to reports of failure of osseointegration, there are very few descriptions of implant rejection since a majority of the implants being used today are made of titanium, a biocompatible material. Additionally, human corticocancellous mineralized allograft bone has been shown as a suitable graft material choice in maxillary sinus augmentation .
As the maxilla is composed of low density cortical bone and short alveolar ridges, there exists the possibility of dental implant failure with other complications such as: maxillary sinusitis, oroantral fistula, and displacement of the dental implant to the maxillary sinus.
Rhinosinusitis is one of the most common diseases in Western societies, causing significant morbidity and resulting in great financial cost to the patient. Although multiple theories have been proposed regarding the underlying pathogenesis (including: allergy, bacterial or fungal infection, genetic predisposition and structural anomalies) at present, the majority of cases are still considered idiopathic [8–12]. In the long list of etiologies, one factor is dental implantation and related post-implant complications .
Rhinosinusitis, defined as inflammation of the nose and paranasal sinuses, most often presents as patients seek medical attention to relieve nasal blockage and discharge. Facial pain/pressure and hyposmia (decrease in the sense of smell) are considered minor symptoms according to the EPOS of 2012. Patients may also suffer from headache, dental pain, halitosis, fatigue, cough, and ear pain during sinusitis [11–15]. Specifically, the reported minor symptoms are common findings with sinusitis occurring as a result of dental infections, therefore it is important to closely and carefully monitor patients in their post-operative follow-up [11, 12].
This retrospective study aims to investigate the relationship of dental implants after sinus lifting with the occurrence of postoperative rhinosinusitis.
In this retrospective case control study, conducted in full accordance with the World Medical Association Declaration of Helsinki and collection of an informed consent from the patients, after an institutional ethical board approval, the records of 94 consecutive patients who received a dental implant between January 2011 and January 2013 at Ev Private Dentistry Clinic were reviewed. A total of 268 implants were placed in these patients, and all had a minimum sinus floor thickness of 5 mm. After local and regional anesthesia administration, all patients underwent a lateral window approach. The sinus membrane was carefully elevated from the sinus floor and medial sinus wall. Human corticocancellous mineralized allograft bone was used as graft material. The same graft materials and implantation techniques were used on all patients. Submerged implants were placed with a drill speed of 750 rpm immediately following the sinus lifting, and prosthetic loading was performed 6 months following the implant placement. Collagen barrier membranes were utilized in cases of mucosal perforation due to manipulation of the area, but otherwise none were placed over the lateral window. The implant did not contact the sinus membrane in any of the patients.
Patients were evaluated for sinus pathology for a period of 5–47 months after bone transplantation and implant insertion using a SNOT-22 questionnaire postoperatively, both pre-operative and post-operative panoramic radiological imaging was employed to monitor the progress of all patients. None of the patients underwent a preoperative CT scan for the purposes of diagnosing their sinus pathology. All patients were questioned for complaints and symptoms of sinusitis preoperatively, and any positive findings were assessed by an otolaryngology consultation. In patients with a diagnosis of sinusitis, an otolaryngologist then performed a full work-up and examination (with nasal endoscopy and CT Scan) and treated the patient accordingly.
Patients were included in the study according to the following criteria: area of missing teeth, a minimum sinus floor thickness of 5 mm, asymptomatic sinus disease, and open airflow. Patients who were either noncompliant with appointments and/or follow-up procedures or had acute sinusitis, were excluded from the study.
Sinusitis can occur as a result of contamination of the maxillary sinus with oral flora in aseptic surgical conditions . Although iatrogenic small sinus membrane perforations during surgery does not seem to be related to the development of postoperative sinusitis in healthy patients, large perforations of the maxillary sinus membrane have a higher likelihood of resulting in a discharge of bony fragments into the maxillary sinus and leading to maxillary sinusitis. Other causes are: ostium obstruction due to postoperative swelling of the maxillary mucosa, blockage of air flow due to diminished intrasinus volume, impaired mucosal activity in the maxillary sinus due to mucosal lacerations, and implant exposure and extensions [17–19].
In their report of 156 dental implant patients with no intraoperative surgical complications, Timmenga et al. showed that small perforations of the sinus membrane (less than 2 mm in diameter) with exposure into the maxillary antrum would often heal spontaneously with normal blood clot formation and routine mucosal healing . As well, in their patients the mucosal lining of the maxillary sinus was not perforated. During postoperative follow-up, 7 patients (4%) developed transient (subacute) sinusitis, and 2 patients (2%) developed chronic purulent maxillary sinusitis.
As surgical procedures themselves can be a possible cause of sinusitis, all patients were operated on under strict adherence to antisepsis guidelines. In our study, the lateral window approach along with submerged implants were used as they are believed to be safer. We used 1–2 mm of allograft for the procedure, since the reabsorption rates can be higher with larger granules, leading to an increased risk of contact between the implant and sinus membrane. Sinus membrane perforation was detected in 8 patients, and a collagen membrane barrier was used to cover the perforation. None of the 8 patients with perforation were part of the group who developed sinusitis.
There have also been studies on the effects of dental implants exposed to the sinus cavity in relation to sinus complications. Raghoebar et al. reported that implants that have undergone extension into the nasal cavity can give rise to rhinosinusitis, and the most likely explanation for this complication is that altered nasal airflow could induce irritation of the nasal mucosa [8, 20]. Figure 2 shows a patient (from a different clinic) who underwent implant placement without sinus lifting and developed subsequent implant-related rhinosiunistis, and is an example of a finding in accordance with the study by Roghoebar et al..
In their study, Sbordone et al. found that the amount of remodeling of the implanted graft depends on the nature of the inlay graft (bovine bone material or autogenous bone from the chin and the iliac crest) with regard to apical measurement, and on the type of procedure of implant insertion (simultaneous or delayed) with regard to cervical measurement. As there was no reported difference in the implant outcome between simultaneous and delayed insertion, we chose to insert the allografts simultaneously. None of the patients in our study experienced extrusion of the implant and no such etiology was found in the patients who developed sinusitis [21–24]. Furthermore, literature shows that not every case of implant extrusion will lead to sinusitis.
Jung et al. reviewed 9 retrospective cases in which 23 implants were placed in the maxillary sinus in such a manner as to allow penetration of the sinus floor by more than 4 mm (mean 5 mm, range 4–7 mm) without lifting the sinus mucous membranes. None of the patients experienced sinusitis, and the study concluded that implant exposure to the maxillary sinus cavity can induce sinus mucous thickening around the implants. They did note, however, that studies involving longer time intervals might be necessary to determine whether the mucosal thickening can become a source of sinusitis [20, 25].
In an animal experimental study, Jung et al. showed that in cases that implants penetrated the mucosa of the sinus floor by more than 4 mm, the portions of the implants extending into the sinus cavity were not fully covered with a newly formed sinus membrane. Therefore, one might expect that implants protruding into the sinus cavity could act as a foreign body and become a source of inflammation and sinusitis. In addition, nasal clearance could be disturbed by implant blockage of the mucociliary pathway, again giving rise to inflammation [20, 26]. None of the patients in the study had a direct penetration of the implant into the sinus cavity, and although some graft reabsorption was seen in the 6-month postoperative radiographs, in no case was the implant in direct contact with the sinus mucosa.
Implant migration is the most serious form of the implant exposition in sinus cavity, and in these cases, patients suffer from severe sinusitis symptoms surgical intervention often performed after completion of medical therapy [27, 28].
One of the limitations of the study is the possibility that patients had a pre-existing localized sinus pathology, which led to postoperative sinusitis. Although this limitation is difficult to avoid due to retrospective nature of the study, those patients who either had complaints of acute sinusitis or questionable results on their panorex film were either seen and cleared by an otolaryngologist or excluded from the study.
As the number of surgical procedures to place implants in the posterior maxilla is rapidly expanding, such complications will probably increase in the future. Studies show that patients who have a history of sinusitis are at a higher risk for developing post-operative sinusitis following a dental implant. Because of this, all patients should be screened for history of sinusitis, and in those who do have a history, a consultation from an Otolaryngologist should be considered as a way of decreasing the risk of complications and increasing the success of the procedure. This will ensure that the patient’s health will not be at risk during the implant or the follow up.
This is a case control study.
- Froum SJ: Dental Implant Complications. Etiology, Prevention and Treatment. 2010, West Sussex: Wiley&SonsGoogle Scholar
- Timmenga NM, Raghoebar GM, Boering G, Weissenbruch R: Maxillary sinus function after sinus lifts for the insertion of dental implants. J Oral Maxillofac Surg. 1997, 5: 936-939.View ArticleGoogle Scholar
- Kretzschmar DP: Rhinosinusitis: review from a dental perspective. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003, 96: 128-135. 10.1016/S1079-2104(03)00306-8.View ArticlePubMedGoogle Scholar
- Chiapasco MF, Felisati G, Gatti F, Di Leo F: The management of complications following displacement of oral implants in the paranasal sinuses: a multicenter clinical report and proposed treatment protocols. Int J Oral Maxillofac Surg. 2009, 38: 1273-1278. 10.1016/j.ijom.2009.09.001.View ArticlePubMedGoogle Scholar
- Sbordone C, Toti P, Guidetti F, Califano L, Pannone G, Sbordone L: Volumetric changes after sinus augmentation using blocks of autogenous iliac bone or freeze-dried allogeneic bone. A non-randomized study. J Cranio Maxillofacial Surg. 2014, 42: 113-118. 10.1016/j.jcms.2013.03.004.View ArticleGoogle Scholar
- Timmenga NM, Raghoebar GM, Weissenbruch R, Vissink A: Maxillary sinusitis after augmentation of the maxillary sinus floor: a report of 2 cases. J Oral Maxillofac Surg. 2001, 59: 200-204. 10.1053/joms.2001.20494.View ArticlePubMedGoogle Scholar
- Ueda M, Kaneda T: Maxillary sinusitis caused by dental implants: report of two cases. J Oral Maxillofac Surg. 1992, 50: 285-287. 10.1016/0278-2391(92)90328-W.View ArticlePubMedGoogle Scholar
- Raghoebar GM, Weissenbruch R, Vissink A: Rhino-sinusitis related to endosseous implants extending into the nasal cavity. A case report. Int J Oral Maxillofac Surg. 2004, 33: 312-314. 10.1006/ijom.2002.0485.View ArticlePubMedGoogle Scholar
- Regev E, Smith RA, Perrott DH, Pogrel MA: Maxillary sinus complications related to endosseous implants. Int J Oral Maxillofac Implants. 1995, 10: 451-461.PubMedGoogle Scholar
- Davis JM, Campbell LA: Fatal air embolism during dental implant surgery: a report of three cases. Can J Anaesth. 1990, 37: 112-121. 10.1007/BF03007491.View ArticleGoogle Scholar
- Fokkens W, Lund V, Mullol J: European position paper on rhinosinusitis and nasal polyps. Rhinology. 2012, 50 (Suppl 23): 1-198.PubMedGoogle Scholar
- Bonfils P, Halimi P, Le Bihan C, Norès JM, Avan P, Landais P: Correlation between nasosinusal symptoms and topographic diagnosis in chronic rhinosinusitis. Ann Otol Rhinol Laryngol. 2005, 114: 74-83. 10.1177/000348940511400114.View ArticlePubMedGoogle Scholar
- Sbordone L, Sbordone C, Toti P, Menchini-Fabris GB, Califano L, Guidetti F: Sinus en block inlay grafting with lateral approach and bone lid replacement: report of a series of cases. J Oral Maxillofac Surg. 2010, 68: 221-226. 10.1016/j.joms.2009.07.052.View ArticlePubMedGoogle Scholar
- Osguthorpe JD, Hadley JA: Rhinosinusitis. Current concepts in evaluation and management. Med Clin North Am. 1999, 83: 27-41. 10.1016/S0025-7125(05)70085-7.View ArticlePubMedGoogle Scholar
- Chiu AG, Kennedy DW: Disadvantages of minimal techniques for surgical management of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2004, 12: 38-42. 10.1097/00020840-200402000-00011.View ArticlePubMedGoogle Scholar
- Misch CE: The pharmacologic management of maxillary sinus elevation surgery. J Oral Implant. 1992, 18: 15-16.Google Scholar
- Drettner B: The permeability of the maxillary ostium. Acta Otolaryngol. 1965, 60: 304-10.3109/00016486509127015.View ArticleGoogle Scholar
- Aust R, Drettner B: Oxygen tension in the human maxillary sinus under normal and pathological conditions. Acta Otolaryngol. 1974, 78: 264-10.3109/00016487409126354.View ArticlePubMedGoogle Scholar
- Timmenga NM, Raghoebar GM, Boering G: Maxillary sinus clearance after sinuslifting for the insertion of dental implants. J Oral Maxillofac Surg. 1997, 55: 936-10.1016/S0278-2391(97)90063-X.View ArticlePubMedGoogle Scholar
- Jung JH, Choi BH, Zhu SJ: The effects of exposing dental implants to the maxillary sinus cavity on sinus complications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 102: 602-604. 10.1016/j.tripleo.2005.10.061.View ArticlePubMedGoogle Scholar
- Sbordone L, Toti P, Menchini-Fabris GB, Sbordone C, Guidetti F: Implant success in sinus-lifted maxillae and native bone: a 3-year clinical and computerized tomographic follow-up. Int J Oral Maxillofac Implants. 2009, 24: 316-324.PubMedGoogle Scholar
- Sbordone L, Levin L, Guidetti F, Sbordone C, Glikman A, Schwartz-Arad D: Apical and marginal bone alterations around implants in maxillary sinus augmentation grafted with autogenous bone or bovine bone material and simultaneous or delayed dental implant positioning. Clin Oral Impl Res. 2011, 22: 485-491. 10.1111/j.1600-0501.2010.02030.x.View ArticleGoogle Scholar
- Sbordone C, Toti P, Guidetti F, Califano L, Bufo P, Sbordone L: Volume changes of autogenous bone after sinus lifting and grafting procedures: a 6-year computerized tomographic follow-up. J Cranio Maxillofacial Surg. 2013, 41: 235-241. 10.1016/j.jcms.2012.09.007.View ArticleGoogle Scholar
- Martuscelli R, Toti P, Sbordone L, Guidetti F, Ramaglia L, Sbordone C: Five-year outcome of bone remodeling around implant in the maxillary sinus: assessment of differences between implants placed into autogenous inlay bone blocks and in ungrafted maxilla. Int J Oral Maxillofac Surg. 2014, 43: 1117-1126. 10.1016/j.ijom.2014.03.016.View ArticlePubMedGoogle Scholar
- Jung JH, Choid BH, Jeong SM, Li J, Lee SH, Lee HJ: A retrospective study of the effects on sinus complications of exposing dental implants to the maxillary sinus cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007, 103: 623-625. 10.1016/j.tripleo.2006.09.024.View ArticlePubMedGoogle Scholar
- Broyne PJ: Analysis of performance of root-form endosseous implants placed in the maxillary sinus. J Long Term Eff Med Implants. 1993, 3: 143-159.Google Scholar
- Branemark PI, Adell R, Albrektsson T, Lekholm U, Lindstrom J, Rockler A: An experimental and clinical study of osseointegrated implants penetrating the nasal cavity and maxillary sinus. J Oral Maxillofac Surg. 1984, 42: 497-505. 10.1016/0278-2391(84)90008-9.View ArticlePubMedGoogle Scholar
- Quiney RE, Brimble E, Hodge M: Maxillary sinusitis from dental osseointegrated implants. J Laryngol Otol. 1990, 104: 333-334. 10.1017/S0022215100112630.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.