Table 1 General characteristic of included studies
From: Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review
First author | Year | Region | Design | Sample size | Mean age | Gender (percentage of males) | Main result | NOS Score |
|---|---|---|---|---|---|---|---|---|
Kusumoto et al. [19] | 2022 | Japan | Retrospective | Total: 271 Group I (cellulitis): 123 Group II (cellulitis with superficial abscess): 61 Group III (profound abscess): 74 Group IV (NSTI): 13 | Total: 61 (41, 74.5) Group I: 56 (37, 71.5) Group II: 59 (40, 77) Group III: 65 (47.3, 73.8) Group IV: 73 (41, 75) | Total: 138 (50.9%) Group I: 60 (48.8%) Group II: 35 (57.4%) Group III: 38 (51.4%) Group IV: 5 (38.5%) | CRP + NLR was an effective tool for diagnosing NSTI and decision-making for CT scan performance. | 7 |
Pavan et al. [18] | 2020 | Brazil | Prospective | Total: 50 Group1(LOS ≤ 3 days): 17 Group2(LOS > 3 days): 33 | Group1: 30.1 ± 15.7 Group2: 32.0 ± 15.6 | Group1: 11 (64.7) Group2: 22 (66.7) | NLR showed a statistically significant and positive correlation concerning LOS. | 6 |
Silva et al. [24] | 2022 | Brazil | Prospective | Total: 66 | Total: 32.7 | a ratio of 1.4:1, with a predominance of male sex | Higher NLR values were significantly associated with greater involvement of fascial regions. | 7 |
Chamora et al. [25] | 2021 | Indonesia | Retrospective | Total: 15 Group1(with DM): 6 Group2(without DM): 9 | Group1: 50.33 ± 9.54 Group2: 33.56 ± 17.78 | Group1: 3 (50) Group2: 6 (66.7) | The mean NLR of patients with DM was lower than patients without DM, and there was no significant association between NLR and therapeutic responses. | 7 |
Dogruel et al. [17] | 2017 | Turkey | Retrospective | Total: 93 Group1(LOS ≤ 1 days): 44 Group2(LOS > 1 days): 49 | Total: 14.50 (7.50–32.00) Group1: 13.00 (8.00–32.00) Group2: 14.00 (7.00–30.00) | Total: 49 (52.1) Group1: 24 (53.3) Group2: 25 (51.0) | NLR was positively and statistically correlated with prolonged LOS, postoperative doses of antibiotics, and also total antibiotic doses. | 8 |
Sakarozi et al. [20] | 2022 | Indonesia | Retrospective | Total: 96 | NA | Total: 60 (62.5) | Significant relationships were observed between NLR and severity, LOS, and mortality in Ludwig’s angina patients. | 7 |
Gallagher et al. [23] | 2021 | England | Retrospective | Total: 161 Group1(LOS ≤ 2 days): 91 Group2(LOS ≥ 3 days): 70 | Total: 38.4 ± 16.8 (5–86) Group1: 36.1 (5–78) Group2: 41.4 (8–86) | Total: 89 (52.7) Group1: 41 (45.1) Group2: 48 (68.6) | NLR can be utilized as a prognostic modality in patients with OI. Patients with NLR ≥ 4.65 are more likely to be hospitalized for two days or more. | 7 |
Rosca et al. [22] | 2022 | Romania | Retrospective | Total: 108 Group1(low-severity infection): 54 Group2(high-severity infection): 54 | Group1: 46.7 ± 17.9 (18–81) Group2: 51.7 ± 18.1 (20–85) | Group1: 30 (55.6) Group2: 36 (66.7) | NLR values observed no statistical significance between groups. However, in logistic regression analysis adjusted for age, gender, and comorbidities, NLR reached statistical significance. | 8 |
Xiaojie et al. [21] | 2021 | China | Retrospective | Total: 18 | Total: 54 (16–75) | Total: 12 (66.6) | NLR was positively correlated with the number of organ involvement. | 7 |