Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study

de Vasconcellos Ferreira, Pedro Maciel; Gomes, Marina de Castro  Monteiro Franco; Almeida, Ana Clara Speziali Menegazzi; Cornélio, Júlia Soares; Arruda, Thiago Jardim; Mafra, Arnoldo; Nunes, Marcelo Henrique Silva; Salera, Rafael Borges; Nogueira, Raquel Fabiane; Sclauser, Juliana Maria Braga; Drummond-Lage, Ana Paula; Rezende, Bruno Almeida

doi:10.1186/s13005-023-00356-3

Table 5 Evaluation of the quality of life by H&N-35 for each group before and after the radiotherapy treatment

From: Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study

H&N-35 domains	GHipo						GConv
H&N-35 domains	n	Mean	SD	Median	Min	Max	n	Mean	SD	Median	Min	Max	p-value^#
Initial evaluation
Pain	23	21.2	29.4	8.3	0.0	83.3	43	19.6	22.0	8.3	0.0	75.0	0.727
Swallowing	23	33.0	32.7	20.8	0.0	100.0	43	17.5	20.2	8.3	0.0	66.7	0.076
Sensory problems	23	9.8	19.0	0.0	0.0	83.3	43	11.1	24.6	0.0	0.0	100.0	0.350
Speech problems	23	36.4	35.8	38.9	0.0	100.0	43	28.9	33.1	11.1	0.0	100.0	0.467
Social eating problems	23	18.7	21.4	4.2	0.0	50.0	43	10.4	17.3	0.0	0.0	66.7	0.193
Social contact problems	23	17.9	23.8	13.3	0.0	86.7	43	10.7	18.7	0.0	0.0	66.7	0.051
Low sex drive	23	45.2	46.9	33.3	0.0	100.0	43	24.9	38.3	0.0	0.0	100.0	0.082
Changes in teeth	23	19.3	35.7	0.0	0.0	100.0	43	17.1	35.3	0.0	0.0	100.0	0.785
Trismus	23	27.3	40.7	0.0	0.0	100.0	43	20.7	34.8	0.0	0.0	100.0	0.621
Xerostomia	23	17.5	34.3	0.0	0.0	100.0	43	24.6	37.8	0.0	0.0	100.0	0.340
Thick saliva	23	48.5	47.9	50.0	0.0	100.0	43	33.4	39.8	33.3	0.0	100.0	0.304
Cough	23	34.8	37.8	33.3	0.0	100.0	43	21.5	33.2	0.0	0.0	100.0	0.138
Feeling unwell	23	51.5	46.8	66.7	0.0	100.0	43	20.0	35.7	0.0	0.0	100.0	< 0.01
Use of analgesics	23	59.1	50.3	100.0	0.0	100.0	43	57.2	49.5	100.0	0.0	100.0	0.860
Nutritional supplements	23	31.8	47.7	0.0	0.0	100.0	43	23.9	42.6	0.0	0.0	100.0	0.556
Tube feeding	23	27.3	45.6	0.0	0.0	100.0	43	7.3	25.8	0.0	0.0	100.0	0.051
Weight loss	23	77.3	42.9	100.0	0.0	100.0	43	43.2	49.5	0.0	0.0	100.0	< 0.01
Weight gain	23	22.7	42.9	0.0	0.0	100.0	43	30.8	46.2	0.0	0.0	100.0	0.440
Final evaluation
Pain	23	47.1	27.2	50.0	0.0	100.0	43	40.5	25.6	33.3	0.0	91.7	0.334
Swallowing	23	52.1	37.8	37.5	0.0	100.0	43	39.8	27.8	33.3	0.0	91.7	0.254
Sensory problems	23	32.5	39.5	8.3	0.0	100.0	43	41.2	31.0	50.0	0.0	100.0	0.265
Speech problems	23	44.2	38.9	33.3	0.0	100.0	43	30.1	31.5	22.2	0.0	100.0	0.207
Social eating problems	23	39.5	27.5	41.7	0.0	100.0	43	31.9	29.2	33.3	0.0	100.0	0.278
Social contact problems	23	16.0	15.7	16.7	0.0	46.7	43	13.4	21.5	0.0	0.0	73.3	0.192
Low sex drive	23	49.1	43.6	66.7	0.0	100.0	43	41.1	43.3	33.3	0.0	100.0	0.526
Changes in teeth	23	9.8	22.9	0.0	0.0	66.7	43	13.3	30.0	0.0	33.3	100.0	0.695
Trismus	23	28.3	40.9	0.0	0.0	100.0	43	29.2	41.0	0.0	0.0	100.0	0.979
Xerostomia	23	38.3	43.6	33.3	0.0	100.0	43	59.0	42.5	66.7	0.0	100.0	0.102
Thick saliva	23	78.3	32.9	100.0	0.0	100.0	43	84.1	30.7	100.0	0.0	100.0	0.486
Cough	23	48.3	39.7	33.3	0.0	100.0	43	27.7	35.7	0.0	0.0	100.0	< 0.05
Feeling unwell	23	33.3	44.6	0.0	0.0	100.0	43	33.3	38.7	33.3	0.0	100.0	0.696
Use of analgesics	23	65.0	48.9	100.0	0.0	100.0	43	65.0	47.7	100.0	0.0	100.0	0.956
Nutritional supplements	23	80.0	41.0	100.0	0.0	100.0	43	72.6	44.7	100.0	0.0	100.0	0.469
Tube feeding	23	40.0	50.3	0.0	0.0	100.0	43	17.7	38.0	0.0	0.0	100.0	0.077
Weight loss	23	90.0	30.8	100.0	0.0	100.0	43	77.6	41.8	100.0	0.0	100.0	0.196
Weight gain	23	10.0	30.8	0.0	0.0	100.0	43	15.0	35.7	0.0	0.0	100.0	0.484

GHipo Hypofractionation group, GCon Conventional group
^#Mann–Whitney’s test

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