Table 3 Association between common variants and cephalometric parameter
SNP-Gene-Function | A1/A2 | Phenotype parameters | BETA | SE | P |
|---|---|---|---|---|---|
rs1051415-JAG1-exon | C/T | Anterior-posterior facial height ratio (%) | 2.50 | 0.86 | 0.0041 |
rs2272591-JAG2-exon | A/G | Mandibular body length (mm) | −2.12 | 0.81 | 0.0093 |
rs10149229-JAG2-exon | A/G | Mandibular body length (mm) | −2.80 | 0.82 | 0.00074 |
rs1057744-JAG2-exon | C/T | Facial angle (°) | 34.08 | 15.41 | 0.028 |
y axis (°) | 1.06 | 0.45 | 0.020 | ||
rs386591752-NOTCH4-exon | T/C | ANB angle (°) | −1.58 | 0.48 | 0.0012 |
Wits appraisal (mm) | −2.42 | 0.72 | 0.0010 | ||
APDI index(°) | 1.79 | 0.64 | 0.0054 | ||
Facial convexity(°) | −3.65 | 1.10 | 0.0011 | ||
Overjet (mm) | −1.69 | 0.53 | 0.0017 | ||
rs372504208-NOTCH2-exon | CGG/C | Articularangle (S-Ar-Go) (°) | −1.89 | 0.83 | 0.025 |
rs1044009-NOTCH3- exon | G/A | APDI index(°) | −1.25 | 0.54 | 0.022 |
rs2304223-DLL3-intron | C/G | ANB angle (°) | −0.73 | 0.34 | 0.033 |
Facial angle (°) | −51.70 | 24.83 | 0.039 | ||
rs20551-EP300-exon | A/G | Midface length (mm) | −2.91 | 1.44 | 0.045 |