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Table 1 Differential diagnosis: Odondogenic fibroma and similar fibrous lesions of jaws.

From: Central odontogenic fibroma: a case report with long-term follow-up


Central odontogenic fibroma

Desmoplastic fibroma

Odontogenic myxoma

Ameloblastic fibroma

Adenomatoid odontogenic tumor


odontogenic ectomesenchyme


odontogenic ectomesenchyme

Odontogenic epithelium and odontogenic ectomesenchyme

Odontogenic epithelium


Interwoven bundles of collagen embedding variable amount of scattered fibroblasts. Many nests and strands of inactive-looking OE** and calcifications can be found [13].

Interlaced bundles and whorled aggregates of densely collagenous tissue containing uniform spindled and elongated fibroblasts/myofibroblasts [2].

Stellate and spindle-shaped cells in a rich myxoid or mucoid stroma with few collagen fibrils. Few OE islands may be present [3, 27].

Branching and anastomosing proliferative OE with peripheral rim of columnar cells in a primitive connective tissue stroma without hard tooth formations [23].

Variably sized solid nodules of cuboidal OE conspicuously with duct-like structures. Eosinophilic amorphous material called "tumor droplets" can be found [28, 29].

Presentation #

1.5% of odontogenic tumors [4]

Age: 34.9+19.6 [12]

M:F *= 1:2.8 [12]

Maxilla and mandible in equal proportions, being most affected posterior (73.5%) and anterior (73.5%) regions, respectively [5, 11].

Less than 1% of bone tumors [21, 30]

Age: 15.1+12 [12, 30]

M:F = 1:1.2 [7, 12]

15% may be painfull [21]

Locally invasive and aggressive

Almost mandible (84%), and in posterior portion of both jaws [21, 30]

3-20% of odontogenic tumors [4]

Age: 31.3 [31]

M:F = 1:2.3 [27]

25% may be painful [27]

Locally invasive and aggressive

Mandible (63%) at posterior region and maxilla at premolar region [31].

1.6% of odontogenic tumors [3]

Age: 9.6 [23]

M:F = 1.26:1

Expansive growth

Mandible (80.5%) posterior (73.5%) [23].

1.7-7% of odontogenic tumors9, OMS

Age:13.2 [28]

M:F = 1:2.6 [28]

The absence of a tooth is observed

Maxilla (twice mandible) at anterior region (92.3%) [32]


Well-defined radiolucency, unilocular in smaller (average of 2.2cm) and multilocular in larger (average of 4.2cm). Pinpoint calcifications may be present in 12% [3].

Well-defined, almost multilocular radiolucency (76%), more likely to involve bone expansion and boundary destruction [21].

Multilocular (60-80%) as "honeycomb", "soap bubble" or "tennis racket" aspect with well-defined borders. Lesions lower than 4.0 cm may be unilocular [22, 27, 31].

Well-defined, uni/multilocular radiolucency, in most cases exhibiting a radiopaque boundary [23, 24].

unilocular radiolucency associated with the crown and often part of the

root of an unerupted tooth, with displacement of neighbouring teeth [28]



Surgical resection/tendency of recurrence [21]

Surgical resection/tendency of recurrence [22]

Surgical resection/tendency of recurrence; malignant transformation in 11.4% [23, 25].

Curettage/excellent [28, 29, 32]

  1. # All tumors generally depicted asymptomatic swellings. *M:F = Masculine:Feminine.**Odontogenic epithelium.