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Table 1 Characteristics of 44 patients with osteoradionecrosis (group 1) and 45 patients in control group (group 2) after postoperative radiotherapy

From: Frequency of osteoradionecrosis of the lower jaw after radiotherapy of oral cancer patients correlated with dosimetric parameters and other risk factors

 

Group 1 (%)

Group 2 (%)

p-value

Median age at RT in years (range)

70.5 (39–94)

71 (42–88)

0.886

Gender

 Male

35 (79.5)

37 (82.2)

0.124

 Female

9 (20.5)

8 (17.8)

T-stage

 1–2

28 (63.6)

32 (71.8)

0.086

 3–4

21 (47.7)

13 (28.9)

Desolate dental status (caries, periodontal disease)

36 (81.8)

17 (37.7)

0.228

Need for pre-RT dental treatment

31 (70.5)

12 (26.7)

0.001

Tooth protection during RT

41 (93.2)

40 (88.9)

0.303

Systemic therapy

 CHT

22 (50.0)

28 (62.2)

0.475

 IT

8 (18.2)

1 (2.2)

 none

14 (31.8)

16 (35.5)

Smoking history

 yes

29 (65.9)

19 (42.2)

0.453

 no

15 (34.1)

26 (57.7)

RT technique

 3D-CRT

7 (15.9)

2 (4.4)

0.519

 IMRT

37 (84.1)

43 (95.6)

Dmean to mandible

  < 45 Gy

25 (56.8)

41 (91.1)

0.023

  > 45 Gy

19 (43.2)

4 (8.9)

Dmax of mandible

  < 50 Gy

2 (4.5)

10 (22.2)

0.033

 51–60 Gy

22 (50.0)

19 (42.2)

  > 60 Gy

20 (45.5)

16 (35.5)

PTV dimension (ccm) (range)

804 (68–4838)

796 (170–1389)

0.028