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Table 2 Risk of OSCC by family history of cancer and head and neck cancer in first- and second-degree relatives after exact matching of cases and controls

From: The role of family history of Cancer in Oral Cavity Cancer

  Cases
n = 255
Controls
n = 255
p-value OR 95% CI
Family history of cancera
Overall family
  Negative 127 (49.8) 130 (51.0) 0.48 0.95 0.82–1.1
  Positive 128 (50.2) 125 (49.0)    
  1 72 (28,2) 67 (26.3)    
  2 31 (12.2) 32 (12.5)    
  3 22 (8.6) 14 (5.5)    
  > 3 3 (1.2) 12 (4.9)    
Parents
  Negative 182 (71.7) 161 (63.4) < 0.05 0.73 0.55–0.98
  Positive 72 (28.3) 90 (36.6)    
  One parent 58 (22.8) 72 (28.3)    
  Both parents 14 (5.5) 18 (8.3)    
Siblings
  Negative 203 (79.9) 221 (87.0) < 0.01 1.59 1.17–2.89
  Positive 51 (20.1) 33 (13.0)    
  1 35 (13,8) 29 (11.4)    
  2 15 (5.9) 4 (1.6)    
  3 1 (0.4) 0    
Children
  Negative 248 (97.2) 250 (98.4) 0.52 1.50 0.42–5.31
  Positive 7 (2.8) 5 (1.6)    
Second degree
  Negative 228 (89.8) 227 (89.4) 0.30 0.87 0.67–1.13
  Positive 26 (10.2) 27 (10.6)    
  1 16 (6.3) 15 (5.9)    
  2 8 (3.1) 5 (2.0)    
  > 2 2 (0.8) 7 (2.8)    
Grandparents
  Negative 244 (96.1) 237 (93.3) 0.06 0.53 0.27–1.03
  Positive 10 (3.9) 17 (6.7)    
  1 10 (3.9) 11 (4.3)    
  2 0 4 (1.6)    
  3 0 2 (0.8)    
Family history of head and neck cancera
 Negative 240 (94.3) 244 (96.6) 0.75 1.11 0.59–2.07
 Positive 15 (5.7) 11 (3.4)    
 1 14 (5.3) 10 (3.0)    
 > 1 1 (0.4) 1 (0.4)    
  1. anumbers do not add to 544 as not all patients reported family history of cancer/head and neck cancer