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Table 2 Survival analysis of RFS for HNM patients according to accomplished SLNB and its results (n = 79). RFS was analyzed by using univariate and multivariate Cox regression

From: Head and neck melanoma: outcome and predictors in a population-based cohort study

  Univariate Cox regression Multivariate Cox regression
p HR Lower
95%-CI
Upper
95%-CI
p HR Lower
95%-CI
Upper
95%-CI
SLNB result No biopsy   1.000     1.000   
Positive SLN <  0.001 14.442 6.974 29.906 0.001 4.046 1.779 9.200
Negative SLN 0.312 1.333 0.763 2.328 0.311 0.717 0.377 1.365
Age at diagnosis <  50   1.000     1.000   
50.0–59.9 0.040 2.794 1.047 7.453 0.002 5.007 1.814 13.882
60.0–69.9 0.021 2.971 1.178 7.493 0.001 5.090 1.963 13.196
70.0–79.9 <  0.001 4.838 2.043 11.460 <  0.001 5.774 2.325 14.336
≥ 80.0 <  0.001 7.343 3.030 17.794 <  0.001 8.875 3.447 22.853
Sex Male   1.000     1.000   
Female 0.136 0.738 0.495 1.101 0.770 1.066 0.694 1.637
UICC stage I   1.000     1.000   
II + III <  0.001 5.501 3.710 8.157 <  0.001 3.752 2.222 6.338
Localisation Scalp and neck   1.000     1.000   
Face 0.021 0.625 0.419 0.931 0.004 0.498 0.309 0.801
CCI classified 0   1.000     1.000   
≥ 1 <  0.001 2.505 1.685 3.725 0.269 1.291 0.821 2.030
Resection margin (mm) <  5   1.000     1.000   
5–9 0.048 0.611 0.375 0.995 0.017 0.532 0.317 0.893
≥ 10 0.437 0.826 0.511 1.336 <  0.001 0.255 0.145 0.450
Histological subgroups Lentigo maligna melanoma   1.000     1.000   
Nodular melanoma <  0.001 5.443 3.339 8.872 <  0.001 4.181 2.220 7.876
Superficial spreading melanoma 0.426 0.792 0.445 1.407 0.885 1.047 0.559 1.964
Melanoma not otherwise specified <  0.001 3.063 1.703 5.512 <  0.001 4.929 2.360 10.293