Table 4 Association between common variants and 5 PCs

PC1

rs1051415

C/T

JAG1

Exon/syn

-0.7298

0.1986

0.0003608

PC1

rs7104987

A/G

MAML2

UTR3

0.2938

0.1219

0.0175

PC1

rs8383

C/AGT

PSEN2

Intronic

0.2925

0.1303

0.02666

PC1

rs7930268

T/CG

MAML2

UTR3

0.2802

0.1254

0.02742

PC1

rs2304214

C/GT

DLL3

Exon/syn

-0.4739

0.2129

0.02793

PC1

rs2304223

C/G

DLL3

Intronic

-0.4739

0.2129

0.02793

PC2

rs1044009

G/AC

NOTCH3

Exon/nonsyn

-0.2354

0.1136

0.0404

PC2

rs741859

C/T

JAG2

UTR3

-0.3261

0.1231

0.009212

PC2

rs957578869

G/T

JAG2

UTR3

0.4257

0.1489

0.005034

PC2

rs1177358515

G/T

EP300

Intronic

0.4909

0.1887

0.01049

PC2

rs10149229

A/CG

JAG2

Intronic

-0.3172

0.1222

0.01068

PC2

rs2272591

A/GT

JAG2

Intronic

-0.3083

0.1211

0.01223

PC2

rs6705408

C/T

ADAM17

UTR3

-0.4671

0.1949

0.01812

PC2

rs2274185

C/G

NCSTN

Intronic

-0.3322

0.156

0.03528

PC2

rs1106317

A/GT

NCOR2

Intronic

0.2442

0.1159

0.03726

PC2

rs9972231

C/AGT

JAG2

Intronic

0.3294

0.1565

0.03748

PC2

rs117649295

G/A

LFNG

UTR3

-0.4966

0.2413

0.04184

PC2

rs28386899

G/A

RFNG

UTR5

0.3577

0.1753

0.04354

PC3

rs165935

C/T

PSEN1

UTR3

-0.3067

0.1388

0.02915

PC3

rs6563

A/CG

NOTCH1

UTR3

0.3215

0.1519

0.03641

PC3

rs1055834488

G/AC

JAG1

UTR5

-0.3348

0.1637

0.04304

PC3

rs10423702

T/C

NOTCH3

Intronic

0.3721

0.1822

0.0434

PC3

rs1044009

G/AC

NOTCH3

Exon/nonsyn

0.3327

0.1496

0.02802

PC3

rs1043996

G/A

NOTCH3

Exon/syn

0.3543

0.1314

0.008049

PC3

rs915894

T/G

NOTCH4

Exon/nonsyn

0.3462

0.1313

0.009514

PC4

rs1033583

T/G

DLL1

UTR3

-0.4583

0.1541

0.003572

PC4

rs2272591 [

A/GT

JAG2

Intronic

-0.3459

0.1345

0.01134

PC4

rs3734776

C/T

DLL1

Intronic

-0.3278

0.1281

0.01176

PC4

rs3741513

T/A

NCOR2

Exon/syn

-0.4064

0.1646

0.01499

PC4

rs3134942

G/T

NOTCH4

Exon/syn

-0.7543

0.3105

0.01664

PC4

rs3134930

C/T

NOTCH4

Intronic

-0.2993

0.1259

0.01907

PC4

rs741859

C/T

JAG2

UTR3

-0.321

0.1376

0.02139

PC4

rs1044507

A/C

NOTCH4

Exon/syn

-0.7504

0.3249

0.02266

PC4

rs7931870

A/G

MAML2

Exon/syn

-0.3707

0.1676

0.02891

PC4

rs2243396

C/GT

DTX1

Intronic

-0.3267

0.149

0.03034

PC4

rs3134798

G/ACT

NOTCH4

Intronic

0.4612

0.2113

0.03109

PC4

rs114763

C/GT

SNW1

Exon/syn

-0.2856

0.1331

0.03401

PC4

rs422951

T/C

NOTCH4

Exon/nonsyn

-0.423

0.1976

0.03435

PC4

rs443198

A/GT

NOTCH4

Exon/syn

0.2815

0.1332

0.03666

PC4

rs3823301

C/T

DLL1

UTR5

-0.3524

0.127

0.006446

PC4

rs10149229

A/G

JAG2

Exon/syn

-0.3708

0.1353

0.007108

PC4

rs915894

T/G

NOTCH4

Exon/nonsyn

0.2567

0.1277

0.04663

PC5

rs79129905

G/A

LFNG

UTR3

-0.4519

0.1827

0.01481

PC5

rs5758235

T/C

EP300

Intronic

-0.3857

0.1426

0.007857

PC5

rs753573114

C/AT

EP300

Intronic

-0.4273

0.1431

0.003452

PC5

rs3818120

G/A

EP300

intronic

-0.3576

0.1395

0.01162

PC5

rs20552

T/ACG

EP300

Exon/syn

0.3761

0.1474

0.01203

PC5

rs17002316

T/C

EP300

intronic

-0.3857

0.1426

0.007857