Targeted sequencing of NOTCH signaling pathway genes and association analysis of variants correlated with mandibular prognathism

Table 2 The associations between SNPs identified in NOTCH signaling pathway genes and MP

SNP-Gene-Function	Genotype/allele				Logistic regression		Statistical Power(%)
SNP-Gene-Function		Cases	Controls	P	OR(95% CI)	P	Statistical Power(%)
rs415929-NOTCH4-EXON	TT	126 (63.3)	142 (72.1)	0.075	1.503 (1.039–2.176)	0.030	39.8
	TC	64 (32.2)	52 (26.4)
	CC	9 (4.5)	3 (1.5)
	T:C	79.4:20.6	85.3:14.7	0.280
rs105415-JAG1-EXON	CC	156 (78.4)	171 (86.8)	0.087	1.708 (1.044–2.784)	0.031	33.91
	CT	40 (20.1)	24 (12.2)
	TT	3 (1.5)	2 (1.0)
	C:T	88.4:11.6	92.9:7.1	0.280
rs423023-NOTCH4-EXON	GG	126 (63.3)	142 (72.1)	0.097	1.480 (1.022–2.144)	0.037	32.2
	GC	65 (32.7)	52 (26.4)
	CC	8 (4.0)	8 (4.1)
	G:C	79.7:20.4	85.3:14.7	0.290
rs7523617-NUMB-UTR3	AA	111 (55.8)	132 (67.0)	0.066	1.417 (1.007–1.995)	0.045	30.05
	AT	79 (39.7)	57 (28.9)
	TT	9 (4.5)	8 (4.1)
	A:T	75.6:24.4	81.5:18.5	0.310
rs520688-NOTCH4-EXON	TT	126 (63.3)	141 (71.6)	0.140	1.445 (1.001–2.085)	0.049	29.06
	TC	64 (32.2)	52 (26.4)
	CC	9 (4.5)	4 (2)
	T:C	79.4:20.6	84.8:15.2	0.320
rs1044006-NOTCH3-EXON	CC	134 (67.3)	116 (58.9)	0.170	0.711 (0.506–0.999)	0.049	29.01
	CT	55 (27.6)	65 (33.0)
	TT	10 (5.1)	16 (8.1)
	C:T	81.2:18.8	75.4:24.6	0.320

ISSN: 1746-160X