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Table 2 The associations between SNPs identified in NOTCH signaling pathway genes and MP

From: Targeted sequencing of NOTCH signaling pathway genes and association analysis of variants correlated with mandibular prognathism

SNP-Gene-Function Genotype/allele Logistic regression Statistical Power(%)
  Cases Controls P OR(95% CI) P
rs415929-NOTCH4-EXON TT 126 (63.3) 142 (72.1) 0.075 1.503 (1.039–2.176) 0.030 39.8
TC 64 (32.2) 52 (26.4)     
CC 9 (4.5) 3 (1.5)     
T:C 79.4:20.6 85.3:14.7 0.280    
rs105415-JAG1-EXON CC 156 (78.4) 171 (86.8) 0.087 1.708 (1.044–2.784) 0.031 33.91
CT 40 (20.1) 24 (12.2)     
TT 3 (1.5) 2 (1.0)     
C:T 88.4:11.6 92.9:7.1 0.280    
rs423023-NOTCH4-EXON GG 126 (63.3) 142 (72.1) 0.097 1.480 (1.022–2.144) 0.037 32.2
GC 65 (32.7) 52 (26.4)     
CC 8 (4.0) 8 (4.1)     
G:C 79.7:20.4 85.3:14.7 0.290    
rs7523617-NUMB-UTR3 AA 111 (55.8) 132 (67.0) 0.066 1.417 (1.007–1.995) 0.045 30.05
AT 79 (39.7) 57 (28.9)     
TT 9 (4.5) 8 (4.1)     
A:T 75.6:24.4 81.5:18.5 0.310    
rs520688-NOTCH4-EXON TT 126 (63.3) 141 (71.6) 0.140 1.445 (1.001–2.085) 0.049 29.06
TC 64 (32.2) 52 (26.4)     
CC 9 (4.5) 4 (2)     
T:C 79.4:20.6 84.8:15.2 0.320    
rs1044006-NOTCH3-EXON CC 134 (67.3) 116 (58.9) 0.170 0.711 (0.506–0.999) 0.049 29.01
CT 55 (27.6) 65 (33.0)     
TT 10 (5.1) 16 (8.1)     
C:T 81.2:18.8 75.4:24.6 0.320