Fig. 1

Transcriptional regulation of inflammatory cytokines and CB receptors in PDL cells upon CII and endocannabinoid treatment. Gene expression analyses were performed for IL-1ß (a), TNFa (b), IL-6 (c), CB1 (d) and CB2 (e) upon challenge with or without AEA (50 μM) or PEA (50 μM) under serum-free conditions in combination with or without CII of PDL cells for 6 h or 10 h, respectively. Analyses were performed via qRT-PCR. Values represent the mean ± SEM (n = 6) of the relative differential gene expression (fold of control). * statistically significant compared to unstimulated control (p < 0.05, one sample t test)