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Table 1 Blake criteria for the diagnosis of CHARGE syndrome

From: CHARGE syndrome: genetic aspects and dental challenges, a review and case presentation

Major criteriaMinor criteria
• Ocular coloboma
• Choanal atresia or stenosis
• Cranial nerve dysfunction or anomaly
• Characteristic ear (external, middle or inner ear)
• Genital hypoplasia
• Developmental delay
• Cardiovascular malformation
• Growth deficiency
• Cleft lip and/or palate
• Distinctive facial features
Definitive diagnosis of CHARGE syndrome:
• 4 major features OR
• 3 Major and 3 minor features
Probable/possible diagnosis of CHARGE syndrome:
• 1–2 major features and several minor features