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Table 2 Expression factors of angiogenesis-related genes and IRS score related to T and N in OSCC samples

From: Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression

Gene/Protein T1 + T2 T3 + T4
  all (n = 56) IRS score (n = 10) N- (n = 39) N+ (n = 17) all (n = 27) IRS score (n = 4) N- (n = 14) N+ (n = 13)
VEGF (NM_001025366) 4.13 ± 2.70 (53) 5.8 4.10 ± 2.40 (37) 4.91 ± 4.15 (16) 4.81 ± 2.32 (27) 7.0 5.32 ± 2.68 (14) 4.25 ± 1.72 (13)
PECAM1 (NM_000442) 0.76 ± 0.40 (41) 0 0.55 ± 0.20 (28) 0.58 ± 0.16 (13) 0.52 ± 0.18 (24) 0 0.49 ± 0.21 (13) 0.54 ± 0.14 (11)
EFNB2 (NM_004093) 2.24 ± 1.08 (46) 4.0 2.06 ± 0.90 (32) 2.56 ± 1.25 (14) 2.39 ± 1.12 (24) 5.5 2.4 0 ± 1.04 (13) 2.39 ± 1.22 (11)
ANGPT1 (NM_001146) 0.51 ± 0.32 (51) 1.2 0.41 ± 0.32 (35) 0.33 ± 0.20 (16) 0.29 ± 0.16 (27) 1.5 0.27 ± 0.15 (14) 0.33 ± 0.18 (13)
ANGPT2 (NM_001147) 3.43 ± 1.73 (52) 5.2 3.52 ± 1.73 (35) 3.51 ± 1.08 (17) 3.91 ± 1.92 (25) 5.8 4.40 ± 1.81 (13) 3.39 ± 1.99 (12)
  1. Expression factors were experimentally determined in relation to a healthy oral mucosa pool with an expression factor of 1; displayed is the median; ± means Standard deviation; number of tumour samples in groups are in brackets