|
Mitochondrial DNA
| |
mutations
|
67%
|
|
p53 gene: Tumor-suppressor genes
|
Cell-cycle regulation Senescence, cell-cycle progression
|
mutations
|
71%
|
|
p16* : Tumor-suppressor genes
|
Cell-cycle regulation Senescence, cell-cycle progression
|
Hypermethylation
|
47%
|
|
DAP-K*
|
kinase whose expression is required for IFN-γ-induced apoptosis
|
Hypermethylation
|
33%
|
|
MGMT*
| |
Hypermethylation
|
23%
|
|
CDKN2A
|
Control of cell cycle, arrest cell cycle at G1& G2act like a Tumor-suppressor genes
|
Hypermethylation
|
30.2%
|
|
CDH1
|
Encodes Ca++ dependent cell to cell adhesions
|
Hypermethylation
|
-
|
|
c-MYCIN: Proto-oncogenes
|
Cell growth, apoptosis
|
amplification
|
20-40%
|
|
Cyclin D oncogenes: Proto-oncogenes
|
Cell-cycle regulation
|
amplification
|
87%
|
