Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

Nicolau Conte-Neto; Alliny Souza Bastos; Rosemary Adriana Chierici Marcantonio; Elcio Marcantonio Junior

doi:10.1186/1746-160X-8-5

Table 4 Management and Outcomes of BRONJ Lesions in Patients with RA

From: Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

Authors	Management	Outcomes
Marunick et al. [4]
Patient 1	ATB + Oral Rinses and sequestrectomy	No healing
Yarom et al. [6]
Patient 2	ATB and curettage + debridement + resection	No healing
Patient 3	ATB and curettage + debridement + resection	Partial healing
Malden & Pai [7]
Patient 4	ATB + CLX + DD and debridement	Progressive improvement
Khamaisi et al. [8]
Patient 5	NA	NA
Marx et al. [9]
Patient6	CLX + DD*	Complete healing
Patient7	CLX + DD*	Complete healing
Patient 8	CLX + DD*	Complete healing
Hamada [10]
Patient 9	CT	Partial Improvement
Barrow [11]
Patient 10	NA	NA
Junquera et al. [12]
Patient 12a	ATB + CLX	Complete healing
Patient 12b	DD and sequestrectomy	Remission of symptoms
Mehanna et al. [13]
Patient 13	ATB + DD + drainage	Complete healing
Favia et al. [14]
Patient 14a	ATB + CLX + DD	Partial Improvement
Patient 14b	ATB + CLX + DD	Partial Improvement
Kwon et al. [15]
Patient 15	Sequestrectomy and CT and resection and debridement + DD	Sequestrectomy: no healing. CT: complete healing in mx and no healing in Md. Resection and debridement: healing after 6 months
Sedghizadeh et al. [16]
Patient 16	ATB + CLX + DD + sequestrectomy + debridement	NA
Lo et al. [17]
Patient 17	ATB + CLX + DD and sequestrectomy + debridement	No healing
Patient 18	ATB + CLX + DD	No healing
Shin et al. [18]
Patient 19	ATB + DD + CLX + debridement	Satisfactory healing
Park et al. [19]
Patient 20	ATB + DD + CLX + curettage	Satisfactory healing
Patient 21	ATB + DD + CLX + curettage	NA
Patient 22	ATB + DD + CLX	Satisfactory healing
Manfredi et al. [20]
Patient 23	DD	NA
Patient 24	DD + ATB + Laser	Partial healing
Patient 25	ATB + Laser	Partial healing
Patient 26	ATB	Partial healing
Conte-Neto et al. [21]
Patient 27	ATB + DD + CLX + sequestrectomy + debridement	Complete healing
Patient 28	ATB + DD + CLX + curettage + debridement	Complete healing

*It was not possible to determine which ATB was prescribed to these patients
ATB antibiotic therapy, CLX chlorhexidine, DD drug discontinuation, CT conservative treatment, NA not available

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