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Table 4 Management and Outcomes of BRONJ Lesions in Patients with RA

From: Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

Authors Management Outcomes
Marunick et al. [4]   
Patient 1 ATB + Oral Rinses and sequestrectomy No healing
Yarom et al. [6]   
Patient 2 ATB and curettage + debridement + resection No healing
Patient 3 ATB and curettage + debridement + resection Partial healing
Malden & Pai [7]   
Patient 4 ATB + CLX + DD and debridement Progressive improvement
Khamaisi et al. [8]   
Patient 5 NA NA
Marx et al. [9]   
Patient6 CLX + DD* Complete healing
Patient7 CLX + DD* Complete healing
Patient 8 CLX + DD* Complete healing
Hamada [10]   
Patient 9 CT Partial Improvement
Barrow [11]   
Patient 10 NA NA
Junquera et al. [12]   
Patient 12a ATB + CLX Complete healing
Patient 12b DD and sequestrectomy Remission of symptoms
Mehanna et al. [13]   
Patient 13 ATB + DD + drainage Complete healing
Favia et al. [14]   
Patient 14a ATB + CLX + DD Partial Improvement
Patient 14b ATB + CLX + DD Partial Improvement
Kwon et al. [15]   
Patient 15 Sequestrectomy and CT and resection and debridement + DD Sequestrectomy: no healing. CT: complete healing in mx and no healing in Md. Resection and debridement: healing after 6 months
Sedghizadeh et al. [16]   
Patient 16 ATB + CLX + DD + sequestrectomy + debridement NA
Lo et al. [17]   
Patient 17 ATB + CLX + DD and sequestrectomy + debridement No healing
Patient 18 ATB + CLX + DD No healing
Shin et al. [18]   
Patient 19 ATB + DD + CLX + debridement Satisfactory healing
Park et al. [19]   
Patient 20 ATB + DD + CLX + curettage Satisfactory healing
Patient 21 ATB + DD + CLX + curettage NA
Patient 22 ATB + DD + CLX Satisfactory healing
Manfredi et al. [20]   
Patient 23 DD NA
Patient 24 DD + ATB + Laser Partial healing
Patient 25 ATB + Laser Partial healing
Patient 26 ATB Partial healing
Conte-Neto et al. [21]   
Patient 27 ATB + DD + CLX + sequestrectomy + debridement Complete healing
Patient 28 ATB + DD + CLX + curettage + debridement Complete healing
  1. *It was not possible to determine which ATB was prescribed to these patients
  2. ATB antibiotic therapy, CLX chlorhexidine, DD drug discontinuation, CT conservative treatment, NA not available