Table 3 Radiographic and Histologic Features of BRONJ Lesions in Patients with RA
Authors | Radiographic features | Histologic features |
|---|---|---|
Marunick et al. [4] | Â | Â |
Patient 1 | Osteolysis + sequestration | Dense nonvital bone + subacutely inflamed granulation tissue + bacterial colonies |
Yarom et al. [6] | Â | Â |
Patient 2 | ID | CLP inflammatory infiltrate + increased vascularity + necrotic bone + bacterial colonies (S. milleri) |
Patient 3 | ID | CLP inflammatory infiltrate + increased vascularity + necrotic bone + bacterial colonies (S. viridans) |
Malden & Pai [7] | Â | Â |
Patient 4 | Thickening of the left sinus floor and bone density alteration (suggestion of a retained root in the upper left second PM) | Sclerotic and necrotic bone |
Khamaisi et al. [8] | Â | Â |
Patient 5 | NA | NA |
Marx et al. [9] | Â | Â |
Patient 6 | NA | NA |
Patient 7 | NA | NA |
Patient 8 | NA | NA |
Hamada [10] | Â | Â |
Patient 9 | NA | NA |
Barrow [11] | Â | Â |
Patient 10 | Widening of the PLS | NA |
Junquera et al. [12] | Â | Â |
Patient 12a | Generalized lytic pattern of bone destruction with superimposed sclerosis of the mandibular ramus | Necrotic osteitis + mixed infiltrate of lymphocytes and granulocytes + medular fibrosis + numerous Actinomyces colonies |
Patient 12b | Â | Â |
Mehanna et al. [13] | Â | Â |
Patient 13 | Marked right neck collection with free gas and midline shift | Normal skin flora with scanty diphtheroids |
Favia et al. [14] | Â | Â |
Patient 14a | ID | NA |
Patient 14b | ID | NA |
Kwon et al. [15] | Â | Â |
Patient 15 | Osteomyelitis characteristics | NA |
Sedghizadeh et al. [16] | Â | Â |
Patient 16 | Ill-defined lytic lesion | NA |
Lo et al. [17] | Â | Â |
Patient 17 | Sequestration osteosclerosis, focal osteolysis with cortical disruption | Actinomyces |
Patient 18 | Irregular area of bony sclerosis | NA |
Shin et al. [18] | Â | Â |
Patient 19 | Alveolar bone resorption with internal scattered residual bone fragments, widening of LPS, and radiolucent lesion | NA |
Park et al. [19] | Â | Â |
Patient 20 | Ill-defined lytic lesion | Necrotic bone + acute and chronic non- specific inflammation + granulation formation |
Patient 21 | Ill-defined lytic lesion | Necrotic bone |
Patient 22 | Ill-defined lytic lesion, mixed radiolucent and radiopaque lesions | NONE |
Manfredi et al.[20] | Â | Â |
Patient 23 | Â | Â |
Patient 24 | NA | NA |
Patient 25 | Â | Â |
Patient 26 | Â | Â |
Conte-Neto et al. [21] | Â | Â |
Patient 27 | Radiolucent lesions and sequestration | Necrotic lamellar bone + chronic and acute inflammatory cells + bacterial colonies |
Patient 28 | Osteosclerosis and osteolysis | NA |