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Table 3 Radiographic and Histologic Features of BRONJ Lesions in Patients with RA
| Authors | Radiographic features | Histologic features |
|---|---|---|
| Marunick et al. [4] | ||
| Patient 1 | Osteolysis + sequestration | Dense nonvital bone + subacutely inflamed granulation tissue + bacterial colonies |
| Yarom et al. [6] | ||
| Patient 2 | ID | CLP inflammatory infiltrate + increased vascularity + necrotic bone + bacterial colonies (S. milleri) |
| Patient 3 | ID | CLP inflammatory infiltrate + increased vascularity + necrotic bone + bacterial colonies (S. viridans) |
| Malden & Pai [7] | ||
| Patient 4 | Thickening of the left sinus floor and bone density alteration (suggestion of a retained root in the upper left second PM) | Sclerotic and necrotic bone |
| Khamaisi et al. [8] | ||
| Patient 5 | NA | NA |
| Marx et al. [9] | ||
| Patient 6 | NA | NA |
| Patient 7 | NA | NA |
| Patient 8 | NA | NA |
| Hamada [10] | ||
| Patient 9 | NA | NA |
| Barrow [11] | ||
| Patient 10 | Widening of the PLS | NA |
| Junquera et al. [12] | ||
| Patient 12a | Generalized lytic pattern of bone destruction with superimposed sclerosis of the mandibular ramus | Necrotic osteitis + mixed infiltrate of lymphocytes and granulocytes + medular fibrosis + numerous Actinomyces colonies |
| Patient 12b | ||
| Mehanna et al. [13] | ||
| Patient 13 | Marked right neck collection with free gas and midline shift | Normal skin flora with scanty diphtheroids |
| Favia et al. [14] | ||
| Patient 14a | ID | NA |
| Patient 14b | ID | NA |
| Kwon et al. [15] | ||
| Patient 15 | Osteomyelitis characteristics | NA |
| Sedghizadeh et al. [16] | ||
| Patient 16 | Ill-defined lytic lesion | NA |
| Lo et al. [17] | ||
| Patient 17 | Sequestration osteosclerosis, focal osteolysis with cortical disruption | Actinomyces |
| Patient 18 | Irregular area of bony sclerosis | NA |
| Shin et al. [18] | ||
| Patient 19 | Alveolar bone resorption with internal scattered residual bone fragments, widening of LPS, and radiolucent lesion | NA |
| Park et al. [19] | ||
| Patient 20 | Ill-defined lytic lesion | Necrotic bone + acute and chronic non- specific inflammation + granulation formation |
| Patient 21 | Ill-defined lytic lesion | Necrotic bone |
| Patient 22 | Ill-defined lytic lesion, mixed radiolucent and radiopaque lesions | NONE |
| Manfredi et al.[20] | ||
| Patient 23 | ||
| Patient 24 | NA | NA |
| Patient 25 | ||
| Patient 26 | ||
| Conte-Neto et al. [21] | ||
| Patient 27 | Radiolucent lesions and sequestration | Necrotic lamellar bone + chronic and acute inflammatory cells + bacterial colonies |
| Patient 28 | Osteosclerosis and osteolysis | NA |
