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Table 2 Clinical features of BRONJ lesions in patients with RA

From: Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

Authors Trigger event Clinical features Stage Site
Marunick et al [4]
Patient 1 Extraction BE + pain + seq├╝estration II Md posterior lingual
Yarom et al [6]
Patient 2 Implants BE + pain + edema + PD + fistula + pathological fracture III Md posterior
Patient 3 Extraction BE + NHS + pain + edema + PD + fistula III Md posterior
Malden & Pai [7]
Patient 4 Extraction BE + pain + NHS + edema III Mx posterior
Khamaisi et al [8]
Patient 5 Dental surgery NA II Md
Marx et al [9]
Patient 6 Spontaneous BE I Md lingual
Patient 7 Palatal CT graft BE + erythema II Mx posterior palate
Patient 8 Spontaneous BE II Md posterior lingual
Hamada [10]
Patient 9 Spontaneous Pain + edema + sequestration II Md
Barrow [11]
Patient 10 Denture trauma BE + pain + PD + erythema II Mx palatine
Junquera et al [12]
Patient 12a Extraction BE + NHS + pain + hypoesthesia + erythema II Md anterior
Patient 12b Spontaneous BE + edema + trismus + pain + swelling II Md posterior lingual
Mehanna et al. [13]
Patient 13 Spontaneous BE + PD + trismus + abscess + pain II Md posterior
Favia et al. [14]
Patient 14a Extraction BE + pain + PD III Mx posterior
Patient 14b Extraction BE + pain + PD III Md posterior
Kwon et al. [15]
Patient 15 Spontaneous BE + PD + edema II Mx and Md posterior
Sedghizadeh et al [16]
Patient 16 Denture trauma BE + pain + infection II/III Mx
Lo et al [17]
Patient 17 Extraction BE + PD edema II Md posterior lingual
Patient 18 Extraction BE + pain + erythema II Mx posterior
Shin et al. [18]
Patient 19 Implants BE + pain + erythema + edema + increased probing depth II Mx posterior
Park et al [19]
Patient 20 Implants Pain + gingival bleeding + PI Pain II Md posterior
Patient 21 Extraction + PD + periodontitis II Mx posterior
Patient 22 Spontaneous Pain + itching sensation + edema III Md posterior and anterior
Manfredi et al. [20]
Patient 23 Spontaneous BE + pain + infection III Md
Patient 24 Spontaneous BE + pain + infection II Md
Patient 25 Spontaneous BE + pain + infection II Md
Patient 26 Extraction BE + pain + infection II Md
Conte-Neto et al. [21]
Patient 27 Spontaneous Pain + infection + increased probing depth + erythema II Md posterior
Patient 28 Spontaneous BE + pain + infection + edema + erythema + increased probing depth + PD II Md posterior
  1. BE Bone exposure, PD purulent discharge, NHS non-healing socket, CT connective tissue, PI periimplantitis, Md mandible, Mx maxillae