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Table 1 Patients and Bisphosphonate Therapy Characteristics
| Authors/Study | Gender | Age | Comorbidities | Medications (Years) |
|---|---|---|---|---|
| Marunick et al. [4] CS Patient 1 | F | 59 | OST | STE + METX + AL (3) |
| Yarom et al. [6] RS | ||||
| Patient 2 | F | 73 | HTN | STE + METX + AL (7), infliximab |
| Patient 3 | F | 76 | HTN + Arrhythmia + hypercholesterolemia | AL (1.5) |
| Malden & Pai [7] CS Patient 4 | F | 56 | NO | STE + AL (1), leflunomide |
| Khamaisi et al. [8] RS Patient 5 | F | 73 | DM | AL (> 0,5) |
| Marx et al. [9] CS | ||||
| Patient6 | F | NA | OST | STE + METX + AL (3.1) |
| Patient 7 | F | NA | OST | STE + METX + AL (6.3) |
| Patient 8 | F | NA | OST | STE + METX + AL (3.3) |
| Hamada [10] CR | ||||
| Patient 9 | F | 68 | OST | STE + RISE (4) |
| Barrow [11] CR | ||||
| Patient 10 | F | 70 | OST | STE + AL (< 3) |
| Junquera et al. [12] CS | ||||
| Patient 12a/12b | M | 73 | NO | STE + METX + AL (3.8) |
| Mehanna et al. [13] CR | ||||
| Patient 13 | F | 55 | NO | STE + Leflunomide + oral BPs (1) |
| Favia et al. [14] CS | ||||
| Patient 14a/14b | F | 67 | OST | STE + IBAN (1) |
| Kwon et al. [15] CR | ||||
| Patient 15 | F | 71 | OST + DM | STE + AL (3); OH |
| Sedghizadeh et al. [16] RS | ||||
| Patient 16 | F | 63 | OST + HTN | STE + chemotherapy + AL (3) |
| Lo et al. [17] RS | ||||
| Patient 17 | NA | NA | NO | oral BPs (4.8) |
| Patient 18 | NA | NA | Hip Osteonecrosis | STE + oral BPs (2.6) |
| Shin et al. [18] CR | ||||
| Patient 19 | F | 67 | OST + HTN | AL (1) + HTN Drug |
| Park et al. [19] CS | ||||
| Patient 20 | F | 68 | OST | STE + AL (5) |
| Patient 21 | F | 69 | OST + PLE + TB | STE + AL (10) |
| Patient 22 | F | 70 | OST + HTN | STE + AL (6) |
| Manfredi et al. [20] CS | ||||
| Patient 23 | F | 68 | OST + DM + HTN | AL (4.25) |
| Patient 24 | F | 65 | OST + HTN | AL (5) |
| Patient 25 | F | 79 | OST | AL (4) |
| Patient 26 | F | 57 | OST + DM + HTN | AL (> 3) |
| Conte-Neto et al. [21] CR | ||||
| Patient 27 | F | 58 | NO | AL (5) |
| Patient 28 | F | 68 | OST | STE + METX + AL (7) |
