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Table 1 Published incidence studies.

From: Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients

Year

Author

Study design

All patients orally examined

Disease

Patients (n)

BP-ONJ cases

Incidence (%)

Used bisphosphonates in BP-ONJ patients

2005

Bamias [24]

pros

no

breast ca

70

2

3

Z, PZ, ZI

    

mult myel

111

11

10

 
    

prostate ca

46

3

7

 
 

Durie [25]

web survey

no

mult myel

904

62

6.9

Z,P

    

breast ca

299

13

4.3

 
 

Guarneri [26]

retro

no

breast ca

48

3

6

P

 

Maerevoet [27]

retro

no

mult myel

194

9

5

P, Z

    

breast ca

    

2006

Badros [28]

retro

yes

mult myel

340

11

3.2

P, Z, PZ

 

Calvo-Villas [29]

retro

no

mult myel

64

7

11

Z

 

Dimopoulos [30]

pros

unclear

mult myel

202

15

7.4

Z, P, ZP, ZI

 

Hoff [31]

retro

no

breast ca

1338

16

1.2

P, Z, PZ

    

mult myel

448

14

3.1

 
 

Sanna [32]

pros

yes

breast ca

81

5

6

P, Z

 

Tosi [33]

retro

no

mult myel

259

9

3.5

Z

 

Zervas [34]

pros

no

mult myel

254

28

11.0

Z, P, ZP

2007

Aguiar Bujanda [35]

css

yes

breast ca

35

4

11

Z

 

Corso [36]

retro

no

mult myel

106

8

8

Z, PZ

 

García Sáenz [37]

pros

no

prostate ca

104

3

3

Z

 

Jadu [38]

retro

yes

mult myel

655

21

3.2

P

 

Mavrokki [39]

estimation

no

malignancies

  

0.9-1.2

 
 

Ortega [40]

retro

no

prostate ca

52

6

12

Z

 

Petrucci [41]

unclear

no

mult myel

311

22

7.1

P, PZ, Z

 

Wang [15]

retro

no

mult myel

292

11

3.8

Z, P, PZ

    

breast ca

81

2

3

 
    

prostate ca

69

2

3

 
 

Wilkinson [42]

retro

no

malignancies

14 349

 

5.48

Z, P, PZ

2008

Boonyapakorn [22]

pros

yes

mult myel

58

10

17

P, PZ, IZ, Z

 

Fehm [43]

retro

no

breast ca

233

10

4.3

Z, ICPZ

 

Ibrahim [44]

retro

no

breast ca

220

5

2.3

PZ, Z

    

mult myel

59

2

3

 
 

Walter [23]

css

yes

prostate ca

43

8

19

IZ, PZ, Z

2009

Walter [45]

retro

no

breast ca

75

4

5.3

Z, PZI

 

this retrospective study

retro

no

mult myel

81

4

4.9

U, PZ

 

this cross-sectional study

css

yes

mult myel

78

16

21

Z, PZ, IZ, PZI

  1. All published studies with BP-ONJ incidences compared to the results of these two studies in the last two lines.
  2. Abbreviations: n, number of patients; BP-ONJ, bisphosphonate-associated osteonecrosis of the jaws; css, cross-sectional study; retro, retrospective study; ca, cancer; mult myel, multiple myeloma; stage I-III, Durie [16] classification; Z, zoledronate; P, pamidronate; I, ibandronate