Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins

Table 4 Adverse microscopic predictors

Cellular level	Large nuclear to cytoplasmic ratio
	Bizarre shaped nuclear staining
	The presence of numerous mitotic figures per field
	The presence of 2 or more stained nucleoli per cell suggesting aneuloploidy
Tissue Level	Punctate staining of cells
	Heaping up of stained cells suggesting rapid cell turnover
	Bizarre sheets of cells
	Distinct tissue borders in unexpected sites e.g. Not at traditional squamo-columnar junctions
	More than 2 visible vessel per high power field suggesting high micro-vessel density

ISSN: 1746-160X