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Table 4 Adverse microscopic predictors

From: Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins

Cellular level Large nuclear to cytoplasmic ratio
  Bizarre shaped nuclear staining
  The presence of numerous mitotic figures per field
  The presence of 2 or more stained nucleoli per cell suggesting aneuloploidy
Tissue Level Punctate staining of cells
  Heaping up of stained cells suggesting rapid cell turnover
  Bizarre sheets of cells
  Distinct tissue borders in unexpected sites e.g. Not at traditional squamo-columnar junctions
  More than 2 visible vessel per high power field suggesting high micro-vessel density