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Table 3 Diagnostic criteria assessed to determine abnormality

From: Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins

Cellular level

Cell: seen in longitudinal tissue plane rather than transverse/depth

 

Cellular morphology, expected histology

 

Nuclear staining pattern- orientation, size, shape, limits

 

Nucleolar staining morphological pattern, orientation

Tissue Level

Cell-cell regularity

 

Extracellular matrix- homogenous, heterogeneous

 

Margin- discrete, blurred

 

Underlying cells, micro-vessel density

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Head & Face Medicine

ISSN: 1746-160X

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