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Table 3 Diagnostic criteria assessed to determine abnormality

From: Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins

Cellular level Cell: seen in longitudinal tissue plane rather than transverse/depth
  Cellular morphology, expected histology
  Nuclear staining pattern- orientation, size, shape, limits
  Nucleolar staining morphological pattern, orientation
Tissue Level Cell-cell regularity
  Extracellular matrix- homogenous, heterogeneous
  Margin- discrete, blurred
  Underlying cells, micro-vessel density