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Table 1 Comparison between ALHE and Kimura's disease.

From: Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?

 

ALHE

Kimura's disease

Presentation

Superficial papules or nodules

Multiple lesions

Large subcutaneous nodules

Usually one lesion

Localisation

Head and neck

Head and neck

Population

Third and fourth decades

Caucasian

Female

Younger age

Asian

Male

Regional lymph nodes

No

Possible

Skeletal involvement

No

Possible

Blood eosinophilia

Mild

Marked

Elevated serum IgE

Infrequent

Frequent

Histology

Marked lymphocytic infiltrate and increased mast cell numbers

Exuberant angiomatoid proliferation, masses of uncanalized epithelioid or histiocytoid endothelial cells

Well developed lymphoid follicles

Capillary proliferation with large thick-walled vessels

Origin of the disease

Vascular origin (endothelial cell)

Chronic inflammatory process