From: Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?
 | ALHE | Kimura's disease |
---|---|---|
Presentation | Superficial papules or nodules Multiple lesions | Large subcutaneous nodules Usually one lesion |
Localisation | Head and neck | Head and neck |
Population | Third and fourth decades Caucasian Female | Younger age Asian Male |
Regional lymph nodes | No | Possible |
Skeletal involvement | No | Possible |
Blood eosinophilia | Mild | Marked |
Elevated serum IgE | Infrequent | Frequent |
Histology | Marked lymphocytic infiltrate and increased mast cell numbers Exuberant angiomatoid proliferation, masses of uncanalized epithelioid or histiocytoid endothelial cells | Well developed lymphoid follicles Capillary proliferation with large thick-walled vessels |
Origin of the disease | Vascular origin (endothelial cell) | Chronic inflammatory process |