Table 1 Comparison between ALHE and Kimura's disease.
From: Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?
| ALHE | Kimura's disease | |
|---|---|---|
| Presentation |
Superficial papules or nodules Multiple lesions |
Large subcutaneous nodules Usually one lesion |
| Localisation | Head and neck | Head and neck |
| Population |
Third and fourth decades Caucasian Female |
Younger age Asian Male |
| Regional lymph nodes | No | Possible |
| Skeletal involvement | No | Possible |
| Blood eosinophilia | Mild | Marked |
| Elevated serum IgE | Infrequent | Frequent |
| Histology |
Marked lymphocytic infiltrate and increased mast cell numbers Exuberant angiomatoid proliferation, masses of uncanalized epithelioid or histiocytoid endothelial cells |
Well developed lymphoid follicles Capillary proliferation with large thick-walled vessels |
| Origin of the disease | Vascular origin (endothelial cell) | Chronic inflammatory process |