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Table 3 PROVEAN human protein batch result

From: Smoothened gene alterations in keratocystic odontogenic tumors

Variation Protein sequence change PROVEAN prediction Sift prediction
Row_No. Protein_ID Position Residue_REF Residue_ALT Score Prediction (cutoff = -2.5) Score Prediction (cutoff = 0.05)
1 NP_005622.1 166 F I -5.385 Deleterious 0.002 Damaging
2 NP_005622.1 334 V G -5.063 Deleterious 0.003 Damaging
3 NP_005622.1 590 S T -1.487 Neutral 0.219 Tolerated
  1. Changes at amino acids 166 and 344 cause a deleterious alteration and a damaging result. The change at amino acid position 590 is relatively neutral and tolerated by the protein.