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Table 3 PROVEAN human protein batch result

From: Smoothened gene alterations in keratocystic odontogenic tumors

Variation

Protein sequence change

PROVEAN prediction

Sift prediction

Row_No.

Protein_ID

Position

Residue_REF

Residue_ALT

Score

Prediction (cutoff = -2.5)

Score

Prediction (cutoff = 0.05)

1

NP_005622.1

166

F

I

-5.385

Deleterious

0.002

Damaging

2

NP_005622.1

334

V

G

-5.063

Deleterious

0.003

Damaging

3

NP_005622.1

590

S

T

-1.487

Neutral

0.219

Tolerated

  1. Changes at amino acids 166 and 344 cause a deleterious alteration and a damaging result. The change at amino acid position 590 is relatively neutral and tolerated by the protein.