Genetic variation (Gene) | Model | Genotype | Normal | Delayed | p-value (Normal vs. Delayed) | Advanced | p-value (Normal vs. Advanced) | |||
n | % | n | % | n | % | |||||
rs708111 (WNT3A) | Co-Dominant | GG | 18 | 33.96 | 5 | 19.23 | Reference | 1 | 6.7 | Reference |
AG | 23 | 43.40 | 10 | 38.46 | 0.685 | 10 | 66.7 | 0.064# | ||
AA | 12 | 22.64 | 11 | 42.31 | 0.066 | 4 | 26.6 | 0.096 | ||
Dominant | GG | 18 | 33.96 | 5 | 19.23 | Reference | 1 | 6.7 | Reference | |
AG + AA | 35 | 66.04 | 21 | 80.77 | 0.175 | 14 | 93.3 | 0.064# | ||
Recessive | GG + AG | 41 | 77.36 | 15 | 57.69 | Reference | 11 | 73.3 | Reference | |
AA | 12 | 22.64 | 11 | 42.31 | 0.070 | 4 | 26.7 | 0.747 | ||
Allele | G | 59 | 55.66 | 20 | 38.46 | Reference | 12 | 40.00 | Reference | |
A | 47 | 44.34 | 32 | 61.54 | 0.042* | 18 | 60.00 | 0.131 | ||
rs1533767 (WNT11) | Co-Dominant | GG | 25 | 60.98 | 7 | 38.89 | Reference | 6 | 50.0 | Reference |
AG | 13 | 31.71 | 11 | 61.11 | 0.059 | 6 | 50.0 | 0.330 | ||
AA | 3 | 7.32 | 0 | 0.00 | † | 0 | 0.0 | † | ||
Dominant | GG | 25 | 60.98 | 7 | 38.89 | Reference | 6 | 50.0 | Reference | |
AG + AA | 16 | 39.02 | 11 | 61.11 | 0.116# | 6 | 50.0 | 0.501 | ||
Recessive | GG + AG | 38 | 92.68 | 18 | 100.00 | Reference | 12 | 100.0 | Reference | |
AA | 3 | 7.32 | 0 | 0.00 | † | 0 | 0.0 | † | ||
Allele | G | 63 | 76.82 | 25 | 69.44 | Reference | 18 | 75.00 | Reference | |
A | 19 | 23.18 | 11 | 30.56 | 0.398 | 6 | 25.00 | 0.853 | ||
rs1200425 (RUNX2) | Co-Dominant | GG | 20 | 37.74 | 7 | 30.43 | Reference | 6 | 42.86 | Reference |
AG | 24 | 45.28 | 8 | 34.78 | 0.826 | 7 | 50.00 | 0.785 | ||
AA | 9 | 16.98 | 8 | 34.78 | 0.266 | 1 | 7.14 | 0.709# | ||
Dominant | GG | 20 | 37.74 | 7 | 30.43 | Reference | 6 | 42.86 | Reference | |
AG + AA | 33 | 62.26 | 16 | 69.57 | 0.541 | 8 | 57.14 | 0.726# | ||
Recessive | GG + AG | 44 | 83.02 | 15 | 65.22 | Reference | 13 | 92.86 | Reference | |
AA | 9 | 16.98 | 8 | 34.78 | 0.087 | 1 | 7.14 | 0.358 | ||
Allele | G | 64 | 60.38 | 22 | 47.83 | Reference | 19 | 67.86 | Reference | |
A | 42 | 39.62 | 24 | 52.17 | 0.151 | 9 | 32.14 | 0.468 | ||
rs59983488 (RUNX2) | Co-Dominant | GG | 18 | 34.62 | 11 | 44.00 | Reference | 7 | 50.00 | Reference |
TG | 13 | 25.00 | 3 | 12.00 | 0.320 | 4 | 28.57 | 0.972 | ||
TT | 21 | 40.38 | 11 | 44.00 | 0.982 | 3 | 21.43 | 0.321 | ||
Dominant | GG | 18 | 34.62 | 11 | 44.00 | Reference | 7 | 50.00 | Reference | |
TG + TT | 34 | 65.38 | 14 | 56.00 | 0.763# | 7 | 50.00 | 0.292# | ||
Recessive | GG + TG | 31 | 59.62 | 14 | 56.00 | Reference | 11 | 78.57 | Reference | |
TT | 21 | 40.38 | 11 | 44.00 | 0.426# | 3 | 21.43 | 0.190# | ||
Allele | G | 49 | 47.12 | 25 | 50.00 | Reference | 18 | 64.29 | Reference | |
T | 55 | 52.88 | 25 | 50.00 | 0.737 | 10 | 35.71 | 0.106 |