Figure 2From: Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation Shows comparative TRAP-staining of the HA-based (A) and the β-TCP-based (B) bone substitutes. The HA-based material only induces the formation of multinucleated giant cells (GC) with few nuclei on its surface, while the β-TCP-based material induces the fusion of voluminous multinucleated giant cells that contain particles of the biomaterial within their cytoplasm (dashed line) (A+B: TRAP-staining, 400x magnification).Back to article page