Skip to main content

Table 4 Management and Outcomes of BRONJ Lesions in Patients with RA

From: Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws

Authors

Management

Outcomes

Marunick et al. [4]

  

Patient 1

ATB + Oral Rinses and sequestrectomy

No healing

Yarom et al. [6]

  

Patient 2

ATB and curettage + debridement + resection

No healing

Patient 3

ATB and curettage + debridement + resection

Partial healing

Malden & Pai [7]

  

Patient 4

ATB + CLX + DD and debridement

Progressive improvement

Khamaisi et al. [8]

  

Patient 5

NA

NA

Marx et al. [9]

  

Patient6

CLX + DD*

Complete healing

Patient7

CLX + DD*

Complete healing

Patient 8

CLX + DD*

Complete healing

Hamada [10]

  

Patient 9

CT

Partial Improvement

Barrow [11]

  

Patient 10

NA

NA

Junquera et al. [12]

  

Patient 12a

ATB + CLX

Complete healing

Patient 12b

DD and sequestrectomy

Remission of symptoms

Mehanna et al. [13]

  

Patient 13

ATB + DD + drainage

Complete healing

Favia et al. [14]

  

Patient 14a

ATB + CLX + DD

Partial Improvement

Patient 14b

ATB + CLX + DD

Partial Improvement

Kwon et al. [15]

  

Patient 15

Sequestrectomy and CT and resection and debridement + DD

Sequestrectomy: no healing. CT: complete healing in mx and no healing in Md. Resection and debridement: healing after 6 months

Sedghizadeh et al. [16]

  

Patient 16

ATB + CLX + DD + sequestrectomy + debridement

NA

Lo et al. [17]

  

Patient 17

ATB + CLX + DD and sequestrectomy + debridement

No healing

Patient 18

ATB + CLX + DD

No healing

Shin et al. [18]

  

Patient 19

ATB + DD + CLX + debridement

Satisfactory healing

Park et al. [19]

  

Patient 20

ATB + DD + CLX + curettage

Satisfactory healing

Patient 21

ATB + DD + CLX + curettage

NA

Patient 22

ATB + DD + CLX

Satisfactory healing

Manfredi et al. [20]

  

Patient 23

DD

NA

Patient 24

DD + ATB + Laser

Partial healing

Patient 25

ATB + Laser

Partial healing

Patient 26

ATB

Partial healing

Conte-Neto et al. [21]

  

Patient 27

ATB + DD + CLX + sequestrectomy + debridement

Complete healing

Patient 28

ATB + DD + CLX + curettage + debridement

Complete healing

  1. *It was not possible to determine which ATB was prescribed to these patients
  2. ATB antibiotic therapy, CLX chlorhexidine, DD drug discontinuation, CT conservative treatment, NA not available