Ewing sarcoma of the mandible mimicking an odontogenic abscess – a case report
© Gosau et al; licensee BioMed Central Ltd. 2008
Received: 15 August 2008
Accepted: 05 November 2008
Published: 05 November 2008
Ewing sarcoma (ES) of the mandible is rare and can be mistaken for inflammation of dental origin. We present a 24-year old male patient which underwent radical tumour surgery and primary reconstruction with a microvascular osteoseptocutaneous free fibular flap as well as postoperative adjuvant chemotherapy. Incomplete osseous tumour resection required a second intervention. This case report recapitulates the clinical and histopathological findings in oral ES, demonstrates its sometimes difficult diagnosis and discusses the (dis-)advantages of primary osseous reconstruction in ablative tumour surgery.
Primary malignant tumours of the jaws are rare and especially the diagnosis and treatment of Ewing sarcoma (ES) (ICD-0 code 9260/3) can be challenging. Less than 3% of all ES originate in the maxillofacial region, usually involving the mandible [1, 2]. 90% occur in the first three decades of life and males are more often affected than females (male:female = 3:2) [1, 3]. Clinical symptoms such as swelling, pain and sensory disturbances are rather unspecific and can sometimes be misleading.
The following case-report is presented to recapitulate the clinical and histopathological findings in oral ES, demonstrate its sometimes difficult diagnosis and discuss the (dis-) advantages of primary osseous reconstruction in ablative tumour surgery.
Four weeks before admission a 24-year-old man noticed a swelling in the right floor of the mouth. Assuming that the tumour was an acute dental abscess the attending dentist incised the tumour and prescribed antibiotics. A temporary decline of the symptoms was noted and root channel treatment, root amputation and splinting of the teeth 43 – 45 due to negative sensibility and loosening was performed. However, the pathologic process of the right mandible enlarged constantly and the patient was referred to our department three weeks after initial treatment.
Swelling, pain, increased CRP, leukocytosis, and elevated temperature may be the first signs of oral ES, occurring also in odontogenic infections [4–6]. In the present case additional apical osteolysis, loss of sensibility and loosening of teeth resulted in root channel treatment, root amputation and splinting of the teeth 43 – 45 with delay of the diagnosis. Root amputation surgery due to large apical osteolytic lesions therefore always requires histopathological evaluation .
ES is a poorly differentiated neuroectodermal tumour with small, round and blue cells [5, 6]. More than 90% of cases show a characteristic translocation t(11;22)(q24;q12) resulting in the fusion of the EWS and FLI-1 genes (Fig. 7f). This gene rearrangement causes a fusion product which functions as an oncogenic aberrant transcription factor with structural variability and potentially prognostic impact . Immunoreactivity against FLI-1 and CD 99 can help to confirm the diagnosis .
Treatment of ES should include wide surgical resection and (neo-)adjuvant chemotherapy .
In the presented case a resection with intraoperative histological control of the soft tissue margins and primary reconstruction of the mandible with a microvascular fibular free flap was performed. On the one hand, immediate bony and soft tissue reconstruction plays a key role in minimizing the deformity created by tumour resection and preventing wound contraction and displacement of bony segments. The combination of ablative and reconstructive surgery within a single procedure reduces the overall treatment time and provides the best aesthetic and functional results [9, 10]. On the other hand it is not possible to control bone margins intraoperatively. Although wide resection based on MRI and CT scans were planned, residual tumour infiltrates were detected in both bony resections margins. Even if MRI scans are performed to assess intramedullar tumour extension, microscopic tumour infiltrates are impossible to detect radiologically . This raises the question whether the aesthetic and functional favourable primary reconstruction or the secondary reconstruction with better control of the bony tumour margins should be favoured.
Oral Ewing sarcoma is a rare tumour entity which can mimic odontogenic inflammation. If root amputation surgery is performed due to an extensive radiolucent lesion, histopathological evaluation should be mandatory. Primary bony reconstruction bears the risk of second intervention when dealing with ES in the mandible.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Talesh KT, Motamedi MHK, Jeihounian M: Ewing's sarcoma of the mandibular condyle: Report of a case. J Oral Maxillofac Surg. 2003, 61: 1216-1219. 10.1016/S0278-2391(03)00686-4.View ArticlePubMedGoogle Scholar
- Bernstein M, Kovar H, Paulussen M, Randall RF, Schuck A, Teot LA, Juergens H: Ewing's sarcoma family of tumors: current management. Oncologist. 2006, 11: 503-519. 10.1634/theoncologist.11-5-503.View ArticlePubMedGoogle Scholar
- Ushigome S, Machinami R, Sorensen PH: Ewing sarcoma/Primitive neuroectodermal tumour (PNET). World Health Organization Classification of Tumours: Pathology and Genetics, Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, IARC Press, Lyon, 298-300.Google Scholar
- Fonseca AS, Mezzalira R, Crespo AN, Bortoleto AE, Paschoal JR: Ewing's sarcoma of the head and neck. Sao Paulo Med J. 2000, 118: 198-200. 10.1590/S1516-31802000000600010.View ArticlePubMedGoogle Scholar
- Dorfmann HD, Czerniak B, Kotz R: WHO classification of tumours of bone: Introduction. World Health Organization Classification of Tumours: Pathology and Genetics, Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, IARC Press, Lyon, France, 227-232.Google Scholar
- Solomon LW, Frustino JL, Loree TR, Brecher ML, Alberico RA, Sullivan M: Ewing sarcoma of the mandibular condyle: multidisciplinary management optimizes outcome. Head Neck. 2008, 30: 405-410. 10.1002/hed.20692.View ArticlePubMedGoogle Scholar
- Kunkel M, Allroggen S, Appel C, Bargholz C, Biffar R, Boehme P, Engel P, Esser W, Fedderwitz J, Frank M, Georgi M, Heurich T, Kopp I, Kreusser B, Reichert TE, Sanner F, Singer R, Staehle HJ, Terheyden H, Wagner W, Wahl G, Weingart D, Werkmeister R, Hülsmann M: Leitlinie Wurzelspitzenresektion. Mund Kiefer Gesichtschir. 2007, 11: 251-257. 10.1007/s10006-007-0075-3.View ArticlePubMedGoogle Scholar
- Schultze-Mosgau S, Thorwarth M, Wehrhahn F, Holter W, Stachel KD, Grabenbauer G, Amann K, Beck JD: Ewing sarcoma of the mandible in a child: interdisciplinary treatment concepts and surgical reconstruction. J Craniofac Surg. 2005, 16: 1140-1146. 10.1097/01.scs.0000180005.52986.19.View ArticlePubMedGoogle Scholar
- Hölzle F, Kesting MR, Hölzle G, Watola A, Loeffelbein DJ, Ervens J, Wolff KD: Clinical outcome and patient satisfaction after mandibular reconstruction with free fibular flaps. Int J Oral Maxillofac Surg. 2007, 36: 802-806. 10.1016/j.ijom.2007.04.013.View ArticlePubMedGoogle Scholar
- Troulis MJ, Williams WB, Kaban LB: Staged protocaol for resection, skeletal reconstruction, and oral rehabilitation of children with jaw tumours. J Oral Maxillofac Surg. 2004, 62: 335-343. 10.1016/j.joms.2003.07.006.View ArticlePubMedGoogle Scholar
- Lopes SL, Almeida SM, Costa AL, Zanardi VA, Cendes F: Imaging findings of Ewing's sarcoma in the mandible. J Oral Sci. 2007, 49: 167-171. 10.2334/josnusd.49.167.View ArticlePubMedGoogle Scholar
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