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Table 1 Interdisciplinary treatment concept for patients with Apert syndrome at the University Hospital of Münster (individual adaptions allowed).

From: The spectrum of Apert syndrome: phenotype, particularities in orthodontic treatment, and characteristics of orthognathic surgery

Stage

Age

Procedure

1

3–6 months

Eradicative-osteoclastic method [35]

2

7–10 years

LeFort III osteotomy +

Frontal advancement +

Protraction face mask immediately postoperatively for 6–12 months (rapid stenosis, problems with anchorage of the orthodontic appliance due to exfoliation of deciduous teeth, and eruption of permanent teeth)

Early LeFort III osteotomy might help to avoid a (second) LeFort III osteotomy at stage 5, and thus reduce surgical risks.

3

> 9 years

Extraction therapy

4

> 10 years

Orthodontic treatment (preparation for orthognathic surgery), retention

5

> 16 years

Orthognathic surgery